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公开(公告)号：EP3334843A1
公开(公告)日：2018-06-20
申请号：EP16834683.1
申请日：2016-08-12
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , C12Q1/6806 , C12Q1/6869 , G01N33/48721 , G06F19/22 , C12Q2525/151 , C12Q2565/631 , C12Q2521/501 , C12Q2525/191 , C12Q2525/197
摘要： Embodiments may include a method of determining a nucleic acid sequence. The method may include receiving a plurality of DNA fragments. The method may also include concatemerizing a first set of the DNA fragments to obtain a concatemer. The method may include performing single-molecule sequencing of the concatemer to obtain a first sequence of the concatemer. In some embodiments, single-molecule sequencing may be performed using a nanopore, and the method may include passing the concatemer through a nanopore. A first electrical signal may then be detected as the concatemer passes through the nanopore. The first electrical signal may correspond to a first sequence of the concatemer. In addition, the method may include analyzing the first electrical signal to determine the first sequence. Subsequences of the first sequence may be aligned to identify sequences corresponding to each of the first set of the DNA fragments.
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公开(公告)号：EP4365307A3
公开(公告)日：2024-07-10
申请号：EP24151720.0
申请日：2020-08-17
发明人： LO, Yuk-Ming Dennis , CHIU, Rossa Wai Kwun , CHAN, Kwan Chee , JIANG, Peiyong , CHENG, Suk Hang , PENG, Wenlei , TSE, On Yee
IPC分类号： G16B40/10 , G16B20/10 , G16B20/20 , G16B40/20 , G16B20/30 , G16B20/00 , G16B30/00 , C12Q1/6869
摘要： We describe a method for detecting a methylation of a cytosine in a nucleic acid molecule. The method comprises receiving data acquired by sequencing a sample nucleic acid molecule by measuring pulses in an optical signal 5 corresponding to nucleotides and obtaining, from the data, values for various properties. An input data structure is created, the input data structure comprising a window of the nucleotides sequenced in the sample nucleic acid molecule. The input date structure is input into a model. Using the model, it is determined whether the methylation is present in the cytosine at the target position within the window in the input data structure.
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公开(公告)号：EP4365307A2
公开(公告)日：2024-05-08
申请号：EP24151720.0
申请日：2020-08-17
发明人： LO, Yuk-Ming Dennis , CHIU, Rossa Wai Kwun , CHAN, Kwan Chee , JIANG, Peiyong , CHENG, Suk Hang , PENG, Wenlei , TSE, On Yee
IPC分类号： C12Q1/6869
摘要： We describe a method for detecting a methylation of a cytosine in a nucleic acid molecule. The method comprises receiving data acquired by sequencing a sample nucleic acid molecule by measuring pulses in an optical signal 5 corresponding to nucleotides and obtaining, from the data, values for various properties. An input data structure is created, the input data structure comprising a window of the nucleotides sequenced in the sample nucleic acid molecule. The input date structure is input into a model. Using the model, it is determined whether the methylation is present in the cytosine at the target position within the window in the input data structure.
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公开(公告)号：EP4069864A1
公开(公告)日：2022-10-12
申请号：EP21751377.9
申请日：2021-02-05
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公开(公告)号：EP4357461A3
公开(公告)日：2024-07-03
申请号：EP24151722.6
申请日：2020-08-17
发明人： LO, Yuk-Ming Dennis , CHIU, Rossa Wai Kwun , CHAN, Kwan Chee , JIANG, Peiyong , CHENG, Suk Hang , PENG, Wenlei , TSE, On Yee
摘要： We describe a method for detection of a methylation of a nucleotide in a nucleic acid molecule. The method comprises receiving a first plurality of first data structures, each first data structure including information measured at nucleotide positions. Then, a plurality of first training samples, each including one of the first plurality of first data structures and a first label is stored. The model is trained using the plurality of first training samples by optimizing parameters of the model based on outputs of the model matching or not matching corresponding labels of the first labels. An output of the model specifies whether the nucleotide has the methylation.
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公开(公告)号：EP4357461A2
公开(公告)日：2024-04-24
申请号：EP24151722.6
申请日：2020-08-17
发明人： LO, Yuk-Ming Dennis , CHIU, Rossa Wai Kwun , CHAN, Kwan Chee , JIANG, Peiyong , CHENG, Suk Hang , PENG, Wenlei , TSE, On Yee
IPC分类号： C12Q1/6869
摘要： We describe a method for detection of a methylation of a nucleotide in a nucleic acid molecule. The method comprises receiving a first plurality of first data structures, each first data structure including information measured at nucleotide positions. Then, a plurality of first training samples, each including one of the first plurality of first data structures and a first label is stored. The model is trained using the plurality of first training samples by optimizing parameters of the model based on outputs of the model matching or not matching corresponding labels of the first labels. An output of the model specifies whether the nucleotide has the methylation.
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公开(公告)号：EP4259817A1
公开(公告)日：2023-10-18
申请号：EP21902599.6
申请日：2021-12-07
发明人： LO, Yuk-Ming Dennis , CHAN, Kwan Chee , JIANG, Peiyong , CHENG, Suk Hang , ZHOU, Ze , XIE, Tingting , WANG, Guangya , DING, Chen
IPC分类号： C12Q1/68
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公开(公告)号：EP4323539A1
公开(公告)日：2024-02-21
申请号：EP22787514.3
申请日：2022-04-12
发明人： LO, Yuk-Ming Dennis , CHIU, Rossa Wai Kwun , CHAN, Kwan Chee , JIANG, Peiyong , CHENG, Suk Hang , DENG, Jiaen
IPC分类号： C12Q1/68
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公开(公告)号：EP3827095A1
公开(公告)日：2021-06-02
申请号：EP19840761.1
申请日：2019-07-23
发明人： LO, Yuk-Ming Dennis , CHIU, Rossa Wai Kwun , CHAN, Kwan Chee , JIANG, Peiyong , CHENG, Suk Hang
IPC分类号： C12Q1/6827 , C12Q1/6869 , C12Q1/6883 , C12Q1/6886
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公开(公告)号：EP3827092A1
公开(公告)日：2021-06-02
申请号：EP20853612.8
申请日：2020-08-17
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