公开(公告)号：EP4399526A1

公开(公告)日：2024-07-17

申请号：EP22868342.1

申请日：2022-09-09

申请人： Grail, LLC

发明人： LARSON, Matthew ,  MAUNTZ, Ruth E. ,  BURKHARDT, David

IPC分类号： G01N33/574 ,  C12Q1/6886 ,  G16B40/00 ,  C12Q1/6809

CPC分类号： G01N33/57415 ,  G01N33/57423 ,  G01N33/57488

公开(公告)号：EP4357455A2

公开(公告)日：2024-04-24

申请号：EP24161229.0

申请日：2017-12-12

申请人： Grail, LLC

发明人： LARSON, Matthew

IPC分类号： C12N15/10

CPC分类号： C12Q1/6844 ,  C12Q1/6853 ,  C12Q1/6855 ,  C12N15/1096 ,  C12Y605/01003 ,  C12Y207/07049

摘要： Aspects of the invention include methods for preparing sequencing libraries comprising a plurality of RNA molecules. In some embodiments, the subject methods comprise sequencing at least a portion of a sequencing library to obtain sequencing data or sequence reads from a test sample (e.g., a biological sample from a subject).

公开(公告)号：EP4259817A1

公开(公告)日：2023-10-18

申请号：EP21902599.6

申请日：2021-12-07

申请人： The Chinese University of Hong Kong ,  Grail, LLC

发明人： LO, Yuk-Ming Dennis ,  CHAN, Kwan Chee ,  JIANG, Peiyong ,  CHENG, Suk Hang ,  ZHOU, Ze ,  XIE, Tingting ,  WANG, Guangya ,  DING, Chen

IPC分类号： C12Q1/68

公开(公告)号：EP4257701A2

公开(公告)日：2023-10-11

申请号：EP23189098.9

申请日：2017-06-29

申请人： Grail, LLC

发明人： LARSON, Matthew ,  KIM, H. John ,  EATTOCK, Nicholas ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6806

摘要： In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.

公开(公告)号：EP4193360A2

公开(公告)日：2023-06-14

申请号：EP21773950.7

申请日：2021-08-26

申请人： Grail, LLC

发明人： SAKARYA, Onur ,  YAKYM, Christopher-James, A., V.

IPC分类号： G16B20/00

公开(公告)号：EP4066245A1

公开(公告)日：2022-10-05

申请号：EP20830402.2

申请日：2020-11-25

申请人： Grail, LLC

发明人： MAHER, M., Cyrus ,  ARAVANIS, Alex ,  LAI, Angela ,  VENN, Oliver, Claude ,  RAVA, Richard ,  XIANG, Jing ,  MARCUS, Joseph

IPC分类号： G16B20/00 ,  G16B40/20 ,  C12Q1/68

公开(公告)号：EP4352747A1

公开(公告)日：2024-04-17

申请号：EP22761742.0

申请日：2022-08-03

申请人： Grail, LLC

发明人： ZHANG, Nan ,  ZHANG, Jing ,  HUBBELL, Earl ,  BRAUN, Jerome Victor ,  SIMON, Noah Robin

IPC分类号： G16H50/50

CPC分类号： G16H50/50

公开(公告)号：EP4257701A3

公开(公告)日：2023-12-20

申请号：EP23189098.9

申请日：2017-06-29

申请人： Grail, LLC

发明人： LARSON, Matthew ,  KIM, H. John ,  EATTOCK, Nicholas ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6806 ,  C12Q1/6869

摘要： In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.

公开(公告)号：EP4193362A1

公开(公告)日：2023-06-14

申请号：EP21790728.6

申请日：2021-09-17

申请人： Grail, LLC

发明人： SAKARYA, Onur ,  YAKYM, Christopher-James, A.V. ,  SINGH, Pranav, Parmjit ,  CALEF, Robert, Abe Paine ,  HUANG, Richard

IPC分类号： G16B30/00 ,  G16B40/20

公开(公告)号：EP4168592A1

公开(公告)日：2023-04-26

申请号：EP21740365.8

申请日：2021-06-17

申请人： Grail, LLC

发明人： CALEF, Robert Abe Paine ,  MAHER, M. Cyrus ,  BEAUSANG, John F. ,  BREDNO, Joerg ,  VENN, Oliver Claude ,  FIELDS, Alexander P. ,  JAMSHIDI, Arash

IPC分类号： C12Q1/6886 ,  C12Q1/70