公开(公告)号：EP2761064A2

公开(公告)日：2014-08-06

申请号：EP12853399.9

申请日：2012-09-27

申请人： The Governing Council Of The University Of Toronto

发明人： SIDHU, Sachdev ,  MOFFAT, Jason ,  PERSSON, Helena ,  PATEL, Nish ,  SUNDARARAJAN, Saravanan ,  GAKHAL, Amandeep ,  YE, Wei ,  TOMIC, Jelena , 

IPC分类号： C40B30/04 ,  C12N15/10 ,  C12Q1/68 ,  C40B20/00 ,  C40B40/02 ,  G01N33/53

CPC分类号： G01N33/6854 ,  C12N15/1037 ,  G01N33/6857

摘要： There is provided herein a method for identifying and/or recovering at least one genetically encoded affinity reagent specific for a target molecule by screening using molecular display in conjunction with the sequencing of positive and negative selection pools from the screen.

公开(公告)号：EP3033356A1

公开(公告)日：2016-06-22

申请号：EP14755545.2

申请日：2014-08-14

申请人： The Governing Council of the University of Toronto

发明人： GAKHAL, Amandeep ,  SIDHU, Sachdev ,  PAN, Guohua ,  MOFFAT, Jason ,  ROBITAILLE, Melanie ,  ANGERS, Stephane

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

摘要： This invention provides monoclonal antibodies that recognize one or more Frizzled receptors. The invention further provides methods of using such monoclonal antibodies as a therapeutic, diagnostic, and prophylactic.