公开(公告)号：EP1185665B1

公开(公告)日：2008-09-10

申请号：EP00939534.4

申请日：2000-06-02

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： BUKH, Jens ,  YANAGI, Masayuki ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： C12N15/51 ,  C07K14/18 ,  C12Q1/68 ,  C12N7/00

CPC分类号： C07K14/005 ,  C07K2319/00 ,  C12N2770/24222

公开(公告)号：EP0998567A2

公开(公告)日：2000-05-10

申请号：EP98935702.5

申请日：1998-07-16

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： YANAGI, Masayuki ,  BUKH, Jens ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： C12N15/40 ,  C07K14/18 ,  C12Q1/70 ,  C07K16/10 ,  A61K39/29

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/525 ,  C07K2319/00 ,  C12N7/00 ,  C12N2770/24221 ,  C12N2770/24222

摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.

公开(公告)号：EP1185664B1

公开(公告)日：2007-05-16

申请号：EP00938146.8

申请日：2000-06-02

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： YANAGI, Masayuki ,  BUKH, Jens ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： C12N15/51 ,  C07K14/18 ,  C07K16/18 ,  A61K38/00 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2770/24222

摘要： The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, genotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.

公开(公告)号：EP1185665A1

公开(公告)日：2002-03-13

申请号：EP00939534.4

申请日：2000-06-02

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： BUKH, Jens ,  YANAGI, Masayuki ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： C12N15/51 ,  C07K14/18 ,  C12Q1/68 ,  C12N7/00

CPC分类号： C07K14/005 ,  C07K2319/00 ,  C12N2770/24222

摘要： The present invention relates to nucleic acid sequence which comprises the genome of an infectious GB virus B clone. The invention also relates to the use of the nucleic acid sequence of the infectious GB virus B clone to indirectly study the molecular properties of HCV, and in the production of HCV/GBV-B chimeras. The invention further relates to the use of the infectious nucleic acid sequence of GB virus B clone and the HCV/GBV-B chimeras in the development of vaccines and therapeutics for HCV.

公开(公告)号：EP1185664A2

公开(公告)日：2002-03-13

申请号：EP00938146.8

申请日：2000-06-02

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： YANAGI, Masayuki ,  BUKH, Jens ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： C12N15/51 ,  C07K14/18 ,  C07K16/18 ,  A61K38/00 ,  A61K39/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C12N2770/24222

摘要： The present invention discloses nucleic acid sequence which encodes infectious hepatitis C virus of strain HC-J6CH, genotype 2a, and the use of the sequence, and polypeptides encoded by all or part of the sequence, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.