公开(公告)号：EP3022206A1

公开(公告)日：2016-05-25

申请号：EP14826591.1

申请日：2014-07-17

申请人： The Hong Kong University of Science and Technology

发明人： IP, Nancy Yuk Yu ,  FU, Kit Yu ,  IP, Fanny Chui Fun ,  FU, Wing Yu ,  GU, Shuo ,  HUANG, Xuhui ,  HUNG, Kwok Wang

IPC分类号： C07D471/20 ,  A61K31/437 ,  A61P25/28

CPC分类号： A61K31/438 ,  A61K31/352 ,  A61K31/402 ,  A61K31/403 ,  A61K31/407 ,  A61K31/437 ,  C07D471/20

摘要： Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving β-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.

摘要翻译： 提供EphA4信号在涉及淀粉样蛋白诱导的神经毒性如神经退行性疾病如阿尔茨海默病中的作用的发现。 提供了用于治疗由过度活化的EphA4信号传导引起或加剧的疾病的新的治疗方法，治疗剂和试剂盒。 还提供了用于鉴定另外的化合物作为治疗剂的方法，所述治疗剂可用于治疗涉及过度活跃的EphA4信号传导的病症。