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公开(公告)号：EP3287458A2
公开(公告)日：2018-02-28
申请号：EP17178305.3
申请日：2011-11-29
发明人： LIU, Jun O , WANG, Jingxin , GUO, Zufeng , LI, Wei , BHAT, Shridhar , DAS, Manisha
IPC分类号： C07D471/04 , C07D498/04 , C07D515/04 , C07D498/14 , A61K31/4353 , A61K31/436 , G01N33/566 , C07D515/14 , C07K17/08
CPC分类号： C07K7/645 , A61K31/4353 , A61K31/436 , C07D471/04 , C07D498/04 , C07D498/14 , C07D515/04 , C07D515/14 , C07K17/08 , G01N33/566
摘要： Provided are novel types of hybrid cyclic libraries of formula (I) that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
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公开(公告)号：EP2646440A2
公开(公告)日：2013-10-09
申请号：EP11844850.5
申请日：2011-11-29
发明人： LIU, Jun, O. , WANG, Jingxin , GUO, Zufeng , LI, Wei , BHAT, Shridhar , DAS, Manisha
IPC分类号： C07D471/04 , C07D498/04 , C07D515/04 , C07D498/14 , A61K31/4353 , A61K31/436
CPC分类号： C07K7/645 , A61K31/4353 , A61K31/436 , C07D471/04 , C07D498/04 , C07D498/14 , C07D515/04 , C07D515/14 , C07K17/08 , G01N33/566
摘要： Provided are novel types of hybrid cyclic libraries of formula (I) that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
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公开(公告)号：EP3287458A3
公开(公告)日：2018-04-11
申请号：EP17178305.3
申请日：2011-11-29
发明人： LIU, Jun O , WANG, Jingxin , GUO, Zufeng , LI, Wei , BHAT, Shridhar , DAS, Manisha
IPC分类号： C07D471/04 , C07D498/04 , C07D515/04 , C07D498/14 , A61K31/4353 , A61K31/436 , G01N33/566 , C07D515/14 , C07K17/08
CPC分类号： C07K7/645 , A61K31/4353 , A61K31/436 , C07D471/04 , C07D498/04 , C07D498/14 , C07D515/04 , C07D515/14 , C07K17/08 , G01N33/566
摘要： Provided are novel types of hybrid cyclic libraries of formula (I) that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
摘要翻译： 提供了包含天然产物的已知蛋白质结合结构域的新型式（I）的杂合环状文库。 还提供了合成方法来制备这样的文库和用于使用部分分裂合并的文库化合物对命中进行解卷积的方法。 这样的方法适用于与整个人类蛋白质组一起使用来筛选结合这些文库并鉴定命中的文库。
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4.发明授权QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS 有权喹啉化合物作为血管生成抑制剂，人蛋氨酸氨肽酶和SIRT1，以及治疗疾病的方法
公开(公告)号：EP2350012B1
公开(公告)日：2017-06-28
申请号：EP09819542.3
申请日：2009-10-06
IPC分类号： C07D215/28 , C07D215/04 , A61K31/47 , A61P35/00 , C07D417/14
CPC分类号： C07D215/04 , A61K31/47 , C07D417/14 , Y02A50/401
摘要： Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1 and/or angiogenesis, wherein a compound of the invention is administered to a subject.
摘要翻译： 本文描述了抑制甲硫氨酸氨肽酶或SirT1，抑制血管生成和治疗与甲硫氨酸氨肽酶，SirT1和/或血管生成相关的病症（或其症状）的方法，其中将本发明的化合物施用于受试者。
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5.发明公开QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS 有权喹啉ALS血管生成，人道和METHIONINAMINOPEPTIDASE- SIRT1抑制剂AND METHOD FOR疾病治疗
公开(公告)号：EP2350012A2
公开(公告)日：2011-08-03
申请号：EP09819542.3
申请日：2009-10-06
IPC分类号： C07D215/28 , C07D215/04 , A61K31/47 , A61P35/00
CPC分类号： C07D215/04 , A61K31/47 , C07D417/14 , Y02A50/401
摘要： Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1 and/or angiogenesis, wherein a compound of the invention is administered to a subject.
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