公开(公告)号：EP3389696A1

公开(公告)日：2018-10-24

申请号：EP16876761.4

申请日：2016-12-16

申请人： The Johns Hopkins University

发明人： LEE, Seulki ,  POMPER, Martin, G. ,  PARK, Jong-Sung ,  OH, Yumin ,  SCULLY, Magdalena ,  HORTON, Maureen

IPC分类号： A61K38/19 ,  A61K39/395 ,  A61P17/00 ,  A61P37/00

CPC分类号： C07K16/2878 ,  A61K38/177 ,  A61K39/39541 ,  A61K47/60 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/75 ,  A61K2300/00

摘要： The present disclosure relates to methods and compositions for treating and/or preventing autoimmune fibrosis, such as systemic sclerosis (SSc; scleroderma). The method includes administering to a subject in need thereof an effective amount of a death receptor agonist. Suitable death receptor agonists include tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL), agonistic death receptor antibodies, and variants, analogues, or derivatives thereof. The administration of the death receptor agonist blocks fibroblast or profibrogenic cell activation, and/or reduces or depletes myofibroblasts, thereby reducing or preventing systemic sclerosis.