专利检索 ap:("The Johns Hopkins University" OR "The Johns Hopkins University") AND inv:"OVERSTREET, Michael, Glen" 第 1 页

1.

发明公开
ANTI-HUMAN B7-H4 ANTIBODIES AND THEIR USES 审中-公开
标题翻译：抗体的人B7-H4及其用途

公开(公告)号：EP2934576A1

公开(公告)日：2015-10-28

申请号：EP13818155.7

申请日：2013-12-19

申请人： The Johns Hopkins University , The Johns Hopkins University

发明人： LANGERMANN, Solomon , LIU, Linda , YAO, Sheng , CHEN, Lieping , OVERSTREET, Michael, Glen

IPC分类号： A61K39/00 , G01N33/68

CPC分类号： C07K16/2827 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/24 , C07K2317/30 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/574

摘要： Anti-human B7-H4 antibody "6H3", antigen-binding fragments, derivatives, and humanized variants thereof that are capable of immunospecifically binding to B7-H4, and the uses of such molecules in the diagnosis and the treatment of cancer and other diseases are disclosed. In preferred embodiments, the molecules are used to retard or prevent tumor growth, inhibit tumor- mediated suppression, eliminate tumors and/or deplete or block the activity of tumor-associated macrophages ("TAMs") so as to alter their activity and/or decrease TAM-mediated immune suppression.