公开(公告)号：EP2401405A1

公开(公告)日：2012-01-04

申请号：EP10746739.1

申请日：2010-02-24

申请人： The Ohio State University Research Foundation ,  The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services

发明人： CROCE, Carlo, M. ,  HARRIS, Curtis, C. ,  SEIKE, Masahiro ,  HORIKAWA, Izumi

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/113 ,  C12N2310/141 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/178

摘要： The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of lung cancer in never- smokers. The invention also provides methods of identifying anti-lung cancer agents.

公开(公告)号：EP2041313B1

公开(公告)日：2011-03-23

申请号：EP07799622.1

申请日：2007-07-16

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： HARRIS, Curtis, C. ,  SEIKE, Masahiro ,  WANG, Xin, Wei

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136

摘要： Methods are disclosed for determining the prognosis of a subject with an adenocarcinoma in an organ, such as the lung. The methods can include quantitating expression of a plurality of cytokines of interest, such as IL-lα, IL-Ib, IL-2, IL-8, IL-IO, IL- 12, IL-15, IFN-γ and TNF-a in the adenocarcinoma and in non-cancerous tissue in the organ. Altered expression of IL-la, IL-Ib, IL-2, IL-8, IL-IO, IL-12, IL-15, IFN-γ and TNF- a in the adenocarcinoma as compared to a control and in non-cancerous tissue in the organ as compared to a control determines the prognosis for the subject. Methods for determining if a therapeutic agent is effective as an anti-cancer agent are also disclosed.

公开(公告)号：EP2041313A2

公开(公告)日：2009-04-01

申请号：EP07799622.1

申请日：2007-07-16

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services

发明人： HARRIS, Curtis, C. ,  SEIKE, Masahiro ,  WANG, Xin, Wei

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136

摘要： Methods are disclosed for determining the prognosis of a subject with an adenocarcinoma in an organ, such as the lung. The methods can include quantitating expression of a plurality of cytokines of interest, such as IL-lα, IL-Ib, IL-2, IL-8, IL-IO, IL- 12, IL-15, IFN-γ and TNF-a in the adenocarcinoma and in non-cancerous tissue in the organ. Altered expression of IL-la, IL-Ib, IL-2, IL-8, IL-IO, IL-12, IL-15, IFN-γ and TNF- a in the adenocarcinoma as compared to a control and in non-cancerous tissue in the organ as compared to a control determines the prognosis for the subject. Methods for determining if a therapeutic agent is effective as an anti-cancer agent are also disclosed.