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3 条记录 (耗时 0.013 秒)

    N-Cadherin as target for cancer diagnosis and therapy
    2.
    发明公开
    N-Cadherin as target for cancer diagnosis and therapy 审中-公开
    N-Cadherin als Zielfürdie Krebsdiagnose und -therapie

    公开(公告)号：EP2390666A1

    公开(公告)日：2011-11-30

    申请号：EP11172878.8

    申请日：2007-03-21

    申请人： The Regents of The University of California

    发明人： Reiter, Robert E.

    IPC分类号： G01N33/574

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  G01N33/57407 ,  G01N33/57434

    摘要： The present invention provides methods of diagnosis, providing a prognosis and a therapeutic target for the treatment of cancers that overexpress N-cadherin and Ly6-E, including prostate and bladder cancers. The invention further provides methods of drug discovery to identify pharmaceutical agents that inhibit or prevent the binding of N-cadherin and Ly6-E to its receptor, which are useful when used alone or in combination with known chemotherapeutics, immunotherapeutics, and radiotherapy for the reversal of resistance, tumor progression, and metastasis of cancers associated with the overexpession of N-cadherin and Ly6-E.

    摘要翻译： 本发明提供诊断方法，提供用于治疗过表达包括前列腺和膀胱癌的N-钙粘蛋白和Ly6-E的癌症的预后和治疗靶标。 本发明进一步提供了药物发现方法，用于鉴定抑制或阻止N-钙粘蛋白和Ly6-E与其受体结合的药物，其当单独使用或与已知的化学治疗剂，免疫治疗剂和放射疗法组合用于逆转时是有用的 与N-cadherin和Ly6-E过度表达相关的癌症的抗药性，肿瘤进展和转移。

    E25a protein, methods for producing and use thereof
    3.
    发明公开
    E25a protein, methods for producing and use thereof 失效
    E25a蛋白，Methoden zur Herstellung und Verwendung

    公开(公告)号：EP1243653A2

    公开(公告)日：2002-09-25

    申请号：EP02014115.6

    申请日：1997-09-05

    申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Reiter, Robert E. ,  Witte, Owen N. ,  Sawyers, Charles L.

    IPC分类号： C12N15/12 ,  C12N15/85 ,  C12N15/11 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/705 ,  C07K16/28 ,  C07K16/46 ,  A61K39/395 ,  A61K48/00 ,  G01N33/53

    CPC分类号： C07K14/705

    摘要： The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding E25a protein, nucleic acid probes which hybridize with nucleic acid molecules encoding E25a protein, and antibodies which bind E25a protein. E25a protein and its related molecules can be useful as diagnostic markers of cancer, including hormone refractory prostate cancer, and as specific therapeutic targets in this disease. The invention also provides methods for diagnosing cancer, including hormone refractory prostate cancer.

    摘要翻译： 本发明提供了在癌细胞中上调的人E25a蛋白，包括激素难治性前列腺癌，结肠癌，乳腺癌或其它上皮癌的癌症。 本发明还提供编码E25a蛋白的核酸分子，与编码E25a蛋白的核酸分子杂交的核酸探针和结合E25a蛋白的抗体。 E25a蛋白及其相关分子可用作癌症的诊断标志物，包括激素难治性前列腺癌，以及作为该疾病的具体治疗靶点。 本发明还提供了诊断癌症的方法，包括激素难治性前列腺癌。