公开(公告)号：EP2588135A2

公开(公告)日：2013-05-08

申请号：EP11801436.4

申请日：2011-06-30

申请人： The Regents of The University of Michigan ,  Nanobio Corporation

发明人： BAKER, Jr., James R. ,  HAMOUDA, Tarek ,  CIOTTI, Susan M.

IPC分类号： A61K39/145 ,  A61K47/48 ,  A61K9/10 ,  A61K9/107 ,  A61P31/00

CPC分类号： A61K9/1075 ,  A61K39/39 ,  A61K2039/55566 ,  C12N2760/16134 ,  Y02A50/394 ,  Y02A50/403 ,  Y02A50/469

摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more immunogens within the oil phase of the nanoemulsion and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the invention find use in, among other things, clinical (e.g., therapeutic and preventative medicine (e.g., vaccination)) and research applications.