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公开(公告)号：EP2588135A2
公开(公告)日：2013-05-08
申请号：EP11801436.4
申请日：2011-06-30
IPC分类号： A61K39/145 , A61K47/48 , A61K9/10 , A61K9/107 , A61P31/00
CPC分类号： A61K9/1075 , A61K39/39 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides nanoemulsion compositions harboring one or more immunogens within the oil phase of the nanoemulsion and methods of using the same for the induction of immune responses (e.g., innate and/or adaptive immune responses (e.g., for generation of host immunity against an environmental pathogen)). Compositions and methods of the invention find use in, among other things, clinical (e.g., therapeutic and preventative medicine (e.g., vaccination)) and research applications.
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公开(公告)号：EP1528937B1
公开(公告)日：2016-08-10
申请号：EP02807914.3
申请日：2002-06-05
发明人： BAKER, James, R. , HAMOUDA, Tarek
IPC分类号： A61K39/39
CPC分类号： A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
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公开(公告)号：EP1242095A1
公开(公告)日：2002-09-25
申请号：EP00989613.5
申请日：2000-12-29
发明人： BAKER, James, R., Jr. , HAMOUDA, Tarek , SHIH, Amy , ANDRZEJ, Myc
IPC分类号： A61K31/665
CPC分类号： A61K9/1075 , A61K45/06 , Y02A50/475 , Y02A50/481 , Y10S514/938
摘要： The present invention relates to a composition comprising an oil-in-water emulsion, said oil-in-water emulsion comprising: a) water; b) oil; c) an alcohol; d) a surfactant, wherein said surfactant is a polysorbate surfactant; and e) a halogen containing compound.
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公开(公告)号：EP1041978A1
公开(公告)日：2000-10-11
申请号：EP98964997.5
申请日：1998-12-28
发明人： BAKER, James, R., Jr. , WRIGHT, D., Craig , HAYES, Michael, M. , HAMOUDA, Tarek , BRISKER, Joan
IPC分类号： A61K31/22 , A61K31/225
CPC分类号： A61K31/661 , A01N25/04 , A01N59/12 , A61K9/107 , A61K31/075 , A61K31/10 , A61K31/185 , A61K31/198 , A61K31/341 , Y02A50/475 , Y02A50/481 , Y10S514/938 , Y10S514/939 , Y10S514/943 , A01N25/30 , A01N2300/00
摘要： Methods for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based solvent. These methods can be used to inactivate a wide variety of bacteria such as Bacillus.
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公开(公告)号：EP1242095B1
公开(公告)日：2013-05-29
申请号：EP00989613.5
申请日：2000-12-29
发明人： BAKER, James, R., Jr. , HAMOUDA, Tarek , SHIH, Amy , ANDRZEJ, Myc
IPC分类号： A61K31/665
CPC分类号： A61K9/1075 , A61K45/06 , Y02A50/475 , Y02A50/481 , Y10S514/938
摘要： The present invention relates to a composition comprising an oil-in-water emulsion, said oil-in-water emulsion comprising: a) water; b) oil; c) an alcohol; d) a surfactant, wherein said surfactant is a polysorbate surfactant; and e) a halogen containing compound.
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公开(公告)号：EP1041978B1
公开(公告)日：2007-03-14
申请号：EP98964997.5
申请日：1998-12-28
发明人： BAKER, James, R., Jr. , WRIGHT, D., Craig , HAYES, Michael, M. , HAMOUDA, Tarek , BRISKER, Joan
CPC分类号： A61K31/661 , A01N25/04 , A01N59/12 , A61K9/107 , A61K31/075 , A61K31/10 , A61K31/185 , A61K31/198 , A61K31/341 , Y02A50/475 , Y02A50/481 , Y10S514/938 , Y10S514/939 , Y10S514/943 , A01N25/30 , A01N2300/00
摘要： Methods for inactivating bacteria including bacterial spores using an oil-in-water emulsion are provided. The oil-in-water emulsion comprises an oil, a surfactant and an organic phosphate-based solvent. These methods can be used to inactivate a wide variety of bacteria such as Bacillus.
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公开(公告)号：EP1528937A2
公开(公告)日：2005-05-11
申请号：EP02807914.3
申请日：2002-06-05
发明人： BAKER, James, R. , HAMOUDA, Tarek
IPC分类号： A61K47/00
CPC分类号： A61K39/39 , A01N25/04 , A61K9/0043 , A61K9/1075 , A61K39/07 , A61K2039/521 , A61K2039/55566 , C12N2760/16134 , Y02A50/394 , Y02A50/403 , Y02A50/469
摘要： The present invention provides methods and compositions for the stimulation of immune responses. Specifically, the present invention provides methods and compositions for the use of nanoemulsion compounds as mucosal adjuvants to induce immunity against environmental pathogens. Accordingly, in some embodiments, the present invention provides nanoemulsion vaccines comprising a nanoemulsion and an inactivated pathogen or protein derived from the pathogen. The present invention thus provides improved vaccines against a variety of environmental and human-released pathogens.
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公开(公告)号：EP2278997B1
公开(公告)日：2016-08-10
申请号：EP09734640.7
申请日：2009-04-21
申请人： Nanobio Corporation
IPC分类号： A61K39/145 , A61K39/00 , A61L2/00
CPC分类号： A61K39/145 , A61K9/0014 , A61K9/0043 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55566 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/16134 , C12N2760/16171 , C12N2760/16234 , C12N2760/16271
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9.发明公开COMPOSITIONS FOR INACTIVATING PATHOGENIC MICROORGANISMS, METHODS OF MAKING THE COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开灭活的病原微生物，方法组合物及其制造使用的成分和方法
公开(公告)号：EP1633322A2
公开(公告)日：2006-03-15
申请号：EP04809431.2
申请日：2004-06-03
申请人： Nanobio Corporation
发明人： BAKER, James, R. , ANNIS, Ted, C. , HAMOUDA, Tarek
IPC分类号： A61K9/00
CPC分类号： A61K31/7048 , A61K9/1075
摘要： Nanoemulsion compositions with low toxicity that demonstrate broad spectrum inactivation of microorganisms or prevention of diseases are described. The nanoemulsions contain an aqueous phase, an oil phase comprising an oil and an organic solvent, and one or more surfactants. Methods of making nanoemulsions and inactivating pathogenic microorganisms are also provided.
摘要翻译： 纳米乳液组合物具有低毒性没表现出微生物或预防疾病的广谱失活中描述。 所述纳米乳剂包含在wässrige相到油相，其包含油和有机溶剂的，和一种或多种表面活性剂。 因此，提供制备纳米乳剂和灭活病原微生物的方法。
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公开(公告)号：EP3023107A1
公开(公告)日：2016-05-25
申请号：EP15182207.9
申请日：2009-04-21
申请人： Nanobio Corporation
IPC分类号： A61K39/145 , A61K39/00 , A61L2/00
CPC分类号： A61K39/145 , A61K9/0014 , A61K9/0043 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5252 , A61K2039/54 , A61K2039/543 , A61K2039/545 , A61K2039/55566 , A61K2039/58 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2760/16134 , C12N2760/16171 , C12N2760/16234 , C12N2760/16271
摘要： The present invention relates to methods for including an immune response to influenza in a subject comprising administering a nanoemulsion vaccine composition comprising an influenza immunogen or protein.
摘要翻译： 本发明涉及在受试者中包括对流感的免疫应答的方法，包括施用包含流感免疫原或蛋白质的纳米乳剂疫苗组合物。
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