公开(公告)号：EP1575658A2

公开(公告)日：2005-09-21

申请号：EP03726286.2

申请日：2003-04-15

申请人： The Regents of the University of California

发明人： ZHOU, Qun-Yong ,  BULLOCK, Clayton, M.

IPC分类号： A61N1/00

CPC分类号： C07K14/47 ,  C07K14/705 ,  G01N33/566 ,  G01N2333/705 ,  G01N2500/04

摘要： The invention provides a method for screening for a compound for modulating circadian rhythm. The method involves (a) providing a compound that is a Prokineticin 2 (PK2) receptor antagonist or agonist; and (b) determining the ability of the compound to modulate one or more indicia of circadian rhythm function, wherein a compound that modulates one or more indicia of circadian rhythm function is identified as a compound for modulating circadian rhythm. The invention also provides a mouse PK2 receptor nucleic acid, polypeptide and related compositions. Further provided is a method for modulating circadian rhythm of an animal, which involves administering an effective amount of a PK2 receptor antagonist or agonist to an animal. Also provided is an isolated nucleic acid comprising a PK2 gene promoter operatively linked to a heterologous nucleotide sequence.