-
1.发明公开
公开(公告)号：EP3439652A1
公开(公告)日：2019-02-13
申请号：EP17779838.6
申请日：2017-04-06
发明人： ZHOU, Qun-Yong
IPC分类号： A61K31/357 , C07D321/10 , C07D405/12
-
公开(公告)号：EP1332157A2
公开(公告)日：2003-08-06
申请号：EP01991024.9
申请日：2001-11-01
摘要： The invention provides isolated polypeptides that stimulate gastroeintestinal smooth muscle contraction, including human prokineticin 1 and human prokineticin 2 polypeptides, and functional fragments and modifications thereof. Also provided are methods of stimulating gastrointestinal smooth muscle contraction in a mammal, by administering to the mammal an effective amount of a prokineticin polypeptide. The invention also provides nucleic acid molecules encoding a prokineticin polypeptide, and antibodies that selectively bind a prokineticin polypeptide. Further provided are methods of identifying a prokineticin receptor ligand, agonist or antagonist.
-
公开(公告)号：EP1572099A2
公开(公告)日：2005-09-14
申请号：EP03776235.8
申请日：2003-10-03
IPC分类号： A61K6/00
CPC分类号： G01N33/6896
摘要： The invention provides methods of identifying compounds that modulate neurogenesis. The methods involve providing a compound that modulates prokineticin receptor signaling; contacting a neural stem or progenitor cell with the compound; and determining the ability of the compound to modulate neurogenesis. The invention also provides methods for modulating neurogenesis. The methods involve contacting a neural stem or progenitor cell with an effective amount of a compound that modulates prokineticin receptor signaling. Such methods are useful for both ex vivo or in vivo therapeutic applications where neural regeneration is desirable.
-
4.发明公开PRIMATE PROKINETICIN AND PROKINETICIN RECEPTOR POLYPEPTIDES, RELATED COMPOSITIONS AND METHODS 审中-公开PROKINETICIN-和PROKINETICINREZEPTOR多肽与灵长类动物，相关的组合物和方法
公开(公告)号：EP1689849A2
公开(公告)日：2006-08-16
申请号：EP04810149.7
申请日：2004-10-29
发明人： ZHOU, Qun-Yong
IPC分类号： C12N1/00
CPC分类号： C07K14/705 , C07K14/47
摘要： The invention provides and isolated squirrel monkey prokineticin receptor 2 (PKR2) polypeptide containing the amino acid sequence referenced as SEQ ID NO:2. The invention also provides an isolated chimpanzee PKR2 containing the amino acid sequence referenced as SEQ ID NO:4. Also provided are methods of identifying PKR2 agonists and antagonists using the squirrel monkey PKR2 polypeptide. Additionally, the invention provides an isolated rhesus monkey PK2 polypeptide containing the amino acid sequence referenced as SEQ ID NO:6. Nucleic acid molecules encoding the disclosed polypeptides further are provided by the invention.
-
5.发明公开
公开(公告)号：EP1575658A2
公开(公告)日：2005-09-21
申请号：EP03726286.2
申请日：2003-04-15
IPC分类号： A61N1/00
CPC分类号： C07K14/47 , C07K14/705 , G01N33/566 , G01N2333/705 , G01N2500/04
摘要： The invention provides a method for screening for a compound for modulating circadian rhythm. The method involves (a) providing a compound that is a Prokineticin 2 (PK2) receptor antagonist or agonist; and (b) determining the ability of the compound to modulate one or more indicia of circadian rhythm function, wherein a compound that modulates one or more indicia of circadian rhythm function is identified as a compound for modulating circadian rhythm. The invention also provides a mouse PK2 receptor nucleic acid, polypeptide and related compositions. Further provided is a method for modulating circadian rhythm of an animal, which involves administering an effective amount of a PK2 receptor antagonist or agonist to an animal. Also provided is an isolated nucleic acid comprising a PK2 gene promoter operatively linked to a heterologous nucleotide sequence.
-
-
-
-
搜索结果
5 条记录 (耗时 0.015 秒)
