公开(公告)号：EP4412624A1

公开(公告)日：2024-08-14

申请号：EP22879435.0

申请日：2022-10-04

申请人： Neuvivo, Inc. ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： AZHIR, Arasteh ,  MCGRATH, Michael S. ,  FORREST, Bruce D. ,  PRICE, Leah

IPC分类号： A61K33/20 ,  A61K33/00 ,  A61P21/00 ,  A61P25/00

CPC分类号： A61K33/00 ,  A61P25/00 ,  A61P21/00 ,  G01N33/6896 ,  G01N2800/2820130101 ,  G01N2800/283520130101

公开(公告)号：EP3142674A1

公开(公告)日：2017-03-22

申请号：EP15792274.1

申请日：2015-05-15

申请人： Neuraltus Pharmaceuticals, Inc. ,  The Regents of the University of California

发明人： MCGRATH, Michael S. ,  BLOCK, Gilbert

IPC分类号： A61K33/20 ,  C01B11/10 ,  A61P25/28

CPC分类号： A61K33/20 ,  A61K33/00 ,  C01B11/10 ,  G01N33/6896 ,  G01N2333/70535 ,  G01N2333/70539 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/52 ,  G01N2800/7095

摘要： Provided herein are methods and composition for the treatment for macrophage-related disorders, for example through the use of biomarkers for selection of responders and treatment monitoring.

摘要翻译： 在提供了用于通过使用生物标志物为应答者和治疗监测的选择治疗巨噬细胞相关的障碍，对于实施例的方法和组合物。

公开(公告)号：EP1711191A2

公开(公告)日：2006-10-18

申请号：EP05722556.7

申请日：2005-01-25

申请人： The Regents of the University of California, Office of the President

发明人： MCGRATH, Michael S.

IPC分类号： A61K33/00

CPC分类号： A61K33/20 ,  A61K9/0019 ,  A61K33/00 ,  A61K33/40 ,  A61K47/02 ,  Y10S514/879 ,  Y10S514/885

摘要： The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease blood immune cell activation. The invention also features methods of monitoring therapy by assessing blood immune cell activation before and after therapy.

摘要翻译： 本发明的特征是有效减少血液免疫细胞活化的亚氯酸盐，用于治疗巨噬细胞相关的神经变性疾病，例如受试者的肌萎缩性侧索硬化（ALS），阿尔茨海默病（AD）或多发性硬化症（MS）。 本发明还描述了通过评估治疗前后的免疫细胞活化来监测治疗的手段。

公开(公告)号：EP3370738A2

公开(公告)日：2018-09-12

申请号：EP16862799.0

申请日：2016-11-01

申请人： Neuraltus Pharmaceuticals, Inc. ,  The Regents of the University of California

发明人： NORVIEL, Vernon A. ,  MCGRATH, Michael S.

IPC分类号： A61K33/20 ,  C01B11/10 ,  A61P25/28

CPC分类号： A61K33/20 ,  A61K45/06

摘要： The present invention provides a method of treating frontotemporal dementia, or a childhood genetic neurodegenerative disease such as Ataxia Telangiectasia (A-T), or neurodegenerative diseases such as Parkinson's disease or neuropsychiatric diseases comprising administering to a subject in need thereof an effective amount of chlorite composition, such as sodium chlorite. The present invention thereby provides a method of modulating the immune system in a subject in need thereof. Described herein are methods of administration and treatment.

公开(公告)号：EP1711191B1

公开(公告)日：2014-03-19

申请号：EP05722556.7

申请日：2005-01-25

申请人： The Regents of the University of California

发明人： MCGRATH, Michael S.

IPC分类号： A61K33/00 ,  A61K33/40 ,  A61K33/20 ,  A61P25/28

CPC分类号： A61K33/20 ,  A61K9/0019 ,  A61K33/00 ,  A61K33/40 ,  A61K47/02 ,  Y10S514/879 ,  Y10S514/885