公开(公告)号：EP4272551A2

公开(公告)日：2023-11-08

申请号：EP23178750.8

申请日：2018-02-26

申请人： The Regents of the University of California

发明人： BLURTON-JONES, Mathew ,  ABUD, Edsel ,  POON, Wayne

IPC分类号： A01K67/027

摘要： Disclosed herein are various embodiments relating to methods of producing iMGLs, for example, from pluripotent stem cells (PSCs), methods of using iMGLs, and compositions of iMGLs. Also disclosed herein are methods to study various neurological disorders, such as for studying Alzheimer's disease. In addition, disclosed herein are methods of investigating genotypic and phenotypic effects of microglia cells in various physiological and pathological environments in the CNS and brain.

公开(公告)号：EP4272551A3

公开(公告)日：2024-03-06

申请号：EP23178750.8

申请日：2018-02-26

申请人： The Regents of the University of California

发明人： BLURTON-JONES, Mathew ,  ABUD, Edsel ,  POON, Wayne

IPC分类号： A61K35/12 ,  A61K35/30 ,  C12N5/00 ,  C12N5/071 ,  C12N5/079 ,  C12N5/0735 ,  C12N5/0789 ,  C12N13/00 ,  A01K67/027 ,  A01K67/0271

摘要： Disclosed herein are various embodiments relating to methods of producing iMGLs, for example, from pluripotent stem cells (PSCs), methods of using iMGLs, and compositions of iMGLs. Also disclosed herein are methods to study various neurological disorders, such as for studying Alzheimer's disease. In addition, disclosed herein are methods of investigating genotypic and phenotypic effects of microglia cells in various physiological and pathological environments in the CNS and brain.

公开(公告)号：EP3589293A1

公开(公告)日：2020-01-08

申请号：EP18760945.8

申请日：2018-02-26

申请人： The Regents of the University of California

发明人： BLURTON-JONES, Mathew ,  ABUD, Edsel ,  POON, Wayne

IPC分类号： A61K35/12 ,  A61K35/30 ,  C12N5/00 ,  C12N5/071 ,  C12N5/079 ,  C12N5/0735 ,  C12N5/0789 ,  C12N13/00