公开(公告)号：EP1514876A2

公开(公告)日：2005-03-16

申请号：EP04012820.9

申请日：1998-03-10

申请人： The Regents of the University of California

发明人： Reiter, Robert ,  Witte, Owen N.

IPC分类号： C07K16/28 ,  A61K47/48 ,  G01N33/53 ,  G01N33/577 ,  G01N33/574 ,  C12Q1/68 ,  C07K14/705 ,  C12N15/12 ,  A61K39/395 ,  A61K39/00 ,  A61P35/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/3069 ,  G01N33/57434

摘要： The invention provides a novel prostate-specific cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

摘要翻译： 本发明提供了一种新的前列腺特异性细胞表面抗原，其命名为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段中广泛过度表达，包括高级前列腺上皮内瘤变（PIN），雄激素依赖性和雄激素 独立前列腺肿瘤。

公开(公告)号：EP1243653A3

公开(公告)日：2003-01-02

申请号：EP02014115.6

申请日：1997-09-05

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Reiter, Robert E. ,  Witte, Owen N. ,  Sawyers, Charles L.

IPC分类号： C12N15/12 ,  C12N15/85 ,  C12N15/11 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/705 ,  C07K16/28 ,  C07K16/46 ,  A61K39/395 ,  A61K48/00 ,  G01N33/53

CPC分类号： C07K14/705

摘要： The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding E25a protein, nucleic acid probes which hybridize with nucleic acid molecules encoding E25a protein, and antibodies which bind E25a protein. E25a protein and its related molecules can be useful as diagnostic markers of cancer, including hormone refractory prostate cancer, and as specific therapeutic targets in this disease. The invention also provides methods for diagnosing cancer, including hormone refractory prostate cancer.

公开(公告)号：EP1514876B1

公开(公告)日：2013-05-08

申请号：EP04012820.9

申请日：1998-03-10

申请人： The Regents of The University of California

发明人： Reiter, Robert ,  Witte, Owen N.

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/3069 ,  G01N33/57434

公开(公告)号：EP2343085A2

公开(公告)日：2011-07-13

申请号：EP10009651.0

申请日：1998-03-10

申请人： The Regents of the University of California

发明人： Reiter, Robert ,  Witte, Owen N.

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K39/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/3069 ,  G01N33/57434

摘要： The invention provides a novel prostate-specific cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

公开(公告)号：EP2343085B1

公开(公告)日：2014-12-10

申请号：EP10009651.0

申请日：1998-03-10

申请人： The Regents of the University of California

发明人： Reiter, Robert ,  Witte, Owen N.

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K39/00 ,  G01N33/574 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/3069 ,  G01N33/57434

公开(公告)号：EP2343085A3

公开(公告)日：2011-10-26

申请号：EP10009651.0

申请日：1998-03-10

申请人： The Regents of the University of California

发明人： Reiter, Robert ,  Witte, Owen N.

IPC分类号： A61K39/395 ,  A61P35/00 ,  A61K39/00 ,  C07K16/30

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/3069 ,  G01N33/57434

摘要： The invention provides a novel prostate-specific cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

摘要翻译： 本发明提供了一种新的前列腺特异性细胞表面抗原，称为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段均广泛过度表达，所述阶段包括高级别前列腺上皮内瘤（PIN），雄激素依赖性和雄激素 独立的前列腺肿瘤。

公开(公告)号：EP1514876A3

公开(公告)日：2007-06-20

申请号：EP04012820.9

申请日：1998-03-10

申请人： The Regents of the University of California

发明人： Reiter, Robert ,  Witte, Owen N.

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/3069 ,  G01N33/57434

摘要： The invention provides a novel prostate-specific cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.

公开(公告)号：EP1243653A2

公开(公告)日：2002-09-25

申请号：EP02014115.6

申请日：1997-09-05

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Reiter, Robert E. ,  Witte, Owen N. ,  Sawyers, Charles L.

IPC分类号： C12N15/12 ,  C12N15/85 ,  C12N15/11 ,  C12N5/10 ,  C12Q1/68 ,  C07K14/705 ,  C07K16/28 ,  C07K16/46 ,  A61K39/395 ,  A61K48/00 ,  G01N33/53

CPC分类号： C07K14/705

摘要： The invention provides a human E25a protein which is upregulated in cancerous cells, including those of hormone refractory prostate cancer, colon cancer, breast cancer or other cancers of epithelial origin. The invention also provides nucleic acid molecules encoding E25a protein, nucleic acid probes which hybridize with nucleic acid molecules encoding E25a protein, and antibodies which bind E25a protein. E25a protein and its related molecules can be useful as diagnostic markers of cancer, including hormone refractory prostate cancer, and as specific therapeutic targets in this disease. The invention also provides methods for diagnosing cancer, including hormone refractory prostate cancer.

摘要翻译： 本发明提供了在癌细胞中上调的人E25a蛋白，包括激素难治性前列腺癌，结肠癌，乳腺癌或其它上皮癌的癌症。 本发明还提供编码E25a蛋白的核酸分子，与编码E25a蛋白的核酸分子杂交的核酸探针和结合E25a蛋白的抗体。 E25a蛋白及其相关分子可用作癌症的诊断标志物，包括激素难治性前列腺癌，以及作为该疾病的具体治疗靶点。 本发明还提供了诊断癌症的方法，包括激素难治性前列腺癌。