公开(公告)号：EP2879669A1

公开(公告)日：2015-06-10

申请号：EP13826030.2

申请日：2013-07-29

申请人： The Regents of The University of Colorado, A Body Corporate

发明人： YIN, Hang ,  CHENG, Kui

IPC分类号： A61K31/122 ,  A61K31/05

CPC分类号： C07C49/747 ,  C07C49/755 ,  C07C62/38 ,  C07C69/21 ,  C07C69/757 ,  C07C235/82 ,  C07C2602/12 ,  C07D307/93

摘要： Provided are compounds, compositions and methods for treating Toll-like receptor 1/2 complex (TLRI/2) related inflammatory disorders. Small molecules, based on the benzotropolone scaffold, capable of influencing downstream signaling are dislcosed as well as methods of making and modifying these molecules. Also provided are methods for treating a subject for a clinical condition associated with Toll¬ like receptor complex 1/2 activation, comprising administering to the subject an effective amount of a benzotropolone compound.

摘要翻译： 提供用于治疗Toll样受体1/2复合物（TLRI / 2）相关的炎症性疾病的化合物，组合物和方法。 公开了能够影响下游信号传导的基于苯佐洛尔酮支架的小分子，以及制备和修饰这些分子的方法。 还提供了用于治疗与Toll样受体复合物1/2活化相关的临床病症的受试者的方法，包括向所述受试者施用有效量的苯佐溴酮化合物。

公开(公告)号：EP2480536B1

公开(公告)日：2014-08-13

申请号：EP10819483.8

申请日：2010-09-23

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： YIN, Hang ,  WATKINS, Linda, R.

IPC分类号： C07D231/12 ,  A61K31/415 ,  A61P25/04 ,  A61P9/00 ,  A61P3/10 ,  C07D213/75

CPC分类号： C07D231/12 ,  C07D213/75

公开(公告)号：EP2838532A2

公开(公告)日：2015-02-25

申请号：EP13778571.3

申请日：2013-04-17

申请人： The Regents of the University of Colorado, a body corporate

发明人： YIN, Hang ,  VARGA, John ,  BHATTACHARYYA, Swati

IPC分类号： A61K31/415 ,  A61P17/00 ,  A61P37/06

CPC分类号： A61K31/415

摘要： The present invention provides a method for treating scleroderma by administering a therapeutically effective amount of a toll like receptor 4 inhibitor to a subject in need of such a treatment.

公开(公告)号：EP2665708A2

公开(公告)日：2013-11-27

申请号：EP12736857.9

申请日：2012-01-13

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： YIN, Hang ,  CHENG, Kui

IPC分类号： C07D209/20 ,  C07D333/58 ,  A61K31/404 ,  A61K31/381 ,  A61P31/00

CPC分类号： C07D333/70 ,  A61K31/381 ,  A61K31/404 ,  C07C311/19 ,  Y02A50/393

摘要： The present invention provides compounds and compositions that can modulate formation of Toll-like receptor 3 (TLR3) and double-stranded RNA (dsRNA) complex, and methods for using the same. In particular, some aspects of the invention provide compounds of the formula: compositions comprising and methods for using the same, where n, Ar1, Ar2, X1, X2, X3, Z1, and Z2 are those defined herein.

公开(公告)号：EP2480536A2

公开(公告)日：2012-08-01

申请号：EP10819483.8

申请日：2010-09-23

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： YIN, Hang ,  WATKINS, Linda, R.

IPC分类号： C07D231/12 ,  A61K31/415 ,  A61P25/04 ,  A61P9/00 ,  A61P3/10

CPC分类号： C07D231/12 ,  C07D213/75

摘要： The present invention provides a compound selected from the group consisting of: Formula (I) and Formula (II), where n, m, X
1 , X
2 , X
3 , X
4 , R
1 , R
2 , R
3 , R
11 , R
12 , Y
1 , Y
2 , Y
3 , Y
4 , and Y
5 are those defined herein. Some aspects of the invention also provides methods for using these compounds and compositions comprising the same.