公开(公告)号：EP4063503A1

公开(公告)日：2022-09-28

申请号：EP22164530.2

申请日：2015-02-11

申请人： The Regents of the University of Colorado, a body corporate

发明人： GILL, Ryan T ,  GARST, Andrew

IPC分类号： C12N15/11 ,  C12N15/00 ,  C12N15/86 ,  A01N63/00 ,  C40B20/04 ,  C40B30/04 ,  C40B40/08 ,  C12N15/10 ,  C12N15/90 ,  C12N9/22

摘要： Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.

公开(公告)号：EP3985114A1

公开(公告)日：2022-04-20

申请号：EP21200160.6

申请日：2015-02-11

申请人： The Regents of the University of Colorado, a body corporate

发明人： GILL, Ryan T ,  GARST, Andrew

IPC分类号： C12N15/11 ,  C12N15/00 ,  C12N15/86 ,  A01N63/00 ,  C40B20/04 ,  C40B30/04 ,  C40B40/08 ,  C12N15/10 ,  C12N15/90 ,  C12N9/22

摘要： Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames ( e.g. , in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.