公开(公告)号：EP2817004B1

公开(公告)日：2018-04-11

申请号：EP13751205.9

申请日：2013-02-21

申请人： The Regents of The University of Colorado, A Body Corporate ,  Suvica, Inc.

发明人： SU, Tin, Tin ,  GLADSTONE, Mara, N. ,  ZHANG, Gan ,  SAMMAKIA, Tarek

IPC分类号： A61N5/10 ,  A61K45/06 ,  A61K31/704 ,  C07K7/06 ,  C07K14/415

CPC分类号： C07K7/64 ,  A61K31/704 ,  A61K38/00 ,  A61K38/12 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098 ,  C07K7/06 ,  C07K14/415 ,  A61K2300/00

摘要： The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.

公开(公告)号：EP3142652A1

公开(公告)日：2017-03-22

申请号：EP15792349.1

申请日：2015-05-14

申请人： The Regents of the University of Colorado, a body corporate

发明人： LIU, Xuedong ,  ZHANG, Gan ,  CHAN, Daniel, Chuen-Fong ,  PISCOPIO, Anthony, D.

IPC分类号： A61K31/165

CPC分类号： C07D513/04 ,  C07D473/16 ,  C07D473/34 ,  C07D487/04

摘要： The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.

摘要翻译： 本发明涉及新型异羟肟酸，其是特定的组蛋白脱乙酰酶（HDAC）抑制剂和/或TTK / MPS1激酶抑制剂，包括其药学上可接受的盐，其是用于调节HDAC和/或TTK / MPS1激酶活性是有用的，药物组合物，包含 合成化合物，以及它们的制备方法。

公开(公告)号：EP2575467B1

公开(公告)日：2016-07-06

申请号：EP11787462.8

申请日：2011-05-26

申请人： The Regents of the University of Colorado, a body corporate

发明人： LIU, Xuedong ,  PHILLIPS, Andrew, J. ,  UNGERMANNOVA, Dana ,  NASVESCHUK, Christopher, G. ,  ZHANG, Gan

IPC分类号： C07K5/08 ,  A01N43/78 ,  A61K31/425

CPC分类号： C07K11/02 ,  A61K31/425 ,  A61K38/005 ,  A61K38/15 ,  A61K39/3955 ,  A61K45/06 ,  C07K5/0821 ,  C07K11/00

公开(公告)号：EP2817004A1

公开(公告)日：2014-12-31

申请号：EP13751205.9

申请日：2013-02-21

申请人： The Regents of The University of Colorado, A Body Corporate ,  Suvica, Inc.

发明人： SU, Tin, Tin ,  GLACSTONE, Mara, N. ,  ZHANG, Gan ,  SAMMAKIA, Tarek

IPC分类号： A61K31/165

CPC分类号： C07K7/64 ,  A61K31/704 ,  A61K38/00 ,  A61K38/12 ,  A61K45/06 ,  A61N5/10 ,  A61N2005/1098 ,  C07K7/06 ,  C07K14/415 ,  A61K2300/00

摘要： The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the compounds inhibit translation elongation at the ribosome. The compounds are used in combination with radiation therapy or with known chemotherapeutic compositions.

公开(公告)号：EP2575467A1

公开(公告)日：2013-04-10

申请号：EP11787462.8

申请日：2011-05-26

申请人： The Regents of the University of Colorado, A Body Corporate

发明人： LIU, Xuedong ,  PHILLIPS, Andrew, J. ,  UNGERMANNOVA, Dana ,  NASVESCHUK, Christopher, G. ,  ZHANG, Gan

IPC分类号： A01N43/78 ,  A61K31/425

CPC分类号： C07K11/02 ,  A61K31/425 ,  A61K38/005 ,  A61K38/15 ,  A61K39/3955 ,  A61K45/06 ,  C07K5/0821 ,  C07K11/00

摘要： The present invention provides a novel macrocyclic compound of general Formula (I) having histone deacetylase (HDAC) inhibitory activity, a pharmaceutical composition comprising the compound, and a method useful to treat diseases using the compound.