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公开(公告)号：EP2435837A2
公开(公告)日：2012-04-04
申请号：EP10781335.4
申请日：2010-05-28
摘要： A metrology probe capable of measurements of a broad range of physical properties of individual samples of nano- or sub-nanometer dimensions is provided. The probe comprises a probe body, a substrate connected to the probe body, and a tip proximate the substrate. The probe further comprises a coarse piezoelectric actuator having an electrical input. The coarse piezo is configured to cause the tip and/or the substrate to move relative to each other when a first electrical signal is provided to the electrical input. The probe further comprises a low- pass filter in electrical communication with the electrical input of the coarse piezo. The probe further comprises a fine piezoelectric actuator having an electrical input configured to cause the tip and/or the substrate to move relative to each other when a second electrical signal is provided to the electrical input.
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公开(公告)号：EP1720998A2
公开(公告)日：2006-11-15
申请号：EP05731009.6
申请日：2005-03-04
发明人： SACHS, Frederick , HUA, Zonglu , BESCH, Stephen , CHOPRA, Harsh, Deep , AUERBACH, Anthony , GOTTLIEB, Philip , ATEYA, Daniel, A.
IPC分类号： C12Q1/02
CPC分类号： G01N15/0266 , G01N33/5026 , G01N33/569
摘要： A method and apparatus for measuring changes in cell volume generally includes introducing cells into a chamber having a volume between 2 and 100 times the volume of the introduced cell. A first electrically conductive extracellular fluid is introduced into the chamber and a current is applied. The current flow is measured. The first fluid is exchanged with a second electrically conductive extracellular fluid and a current is applied. The current flow is measured. The first current flow result and the second current flow result are used in conjunction with known current flows to monitor changes in the volume corresponding to fluid flow between the cell and an extracellular fluid.
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