公开(公告)号：EP2471938A3

公开(公告)日：2013-04-24

申请号：EP12161534.8

申请日：2005-11-24

申请人： The Research Foundation for Microbial Diseases of Osaka University ,  National Institute of Biomedical Innovation

发明人： Mori, Yasuko ,  Somboonthum, Pranee ,  Yoshii, Hironori ,  Gomi, Yasuyuki ,  Takahashi, Michiaki ,  Yamanishi, Koichi

IPC分类号： C12N15/869 ,  A61K39/165 ,  A61K39/25 ,  A61K39/295 ,  A61P31/22 ,  A61P37/04 ,  C12N5/00 ,  C12N7/00

CPC分类号： A61K39/25 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16762 ,  C12N2760/18734 ,  C12N2800/204 ,  C12N2800/50 ,  C12N2820/55 ,  Y02A50/39 ,  Y02A50/394

摘要： The problems to be solved by the present invention are to provide: a recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing a recombinant varicella-zoster virus; a vector containing a BAC vector sequence in the specific gene of a genomic gene of varicella-zoster virus; cells containing such a vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; a nucleic acid cassette containing the BAC vector sequence; and a multivalent vaccine. The above problems were solved by developing a process for producing a recombinant varicella-zoster virus, wherein the BAC vector sequence is inserted into a specific virus gene.

公开(公告)号：EP2471936A3

公开(公告)日：2013-04-24

申请号：EP12161495.2

申请日：2005-11-24

申请人： The Research Foundation for Microbial Diseases of Osaka University ,  National Institute of Biomedical Innovation

发明人： Mori, Yasuko ,  Somboonthum, Pranee ,  Yoshii, Hironori ,  Gomi, Yasuyuki ,  Takahashi, Michiaki ,  Yamanishi, Koichi

IPC分类号： C12N15/869 ,  A61K39/165 ,  A61K39/25 ,  A61K39/295 ,  A61P31/22 ,  A61P37/04 ,  C12N5/00 ,  C12N7/00

CPC分类号： A61K39/25 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16762 ,  C12N2760/18734 ,  C12N2800/204 ,  C12N2800/50 ,  C12N2820/55 ,  Y02A50/39 ,  Y02A50/394

摘要： The problems to be solved by the present invention are to provide: a recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing a recombinant varicella-zoster virus; a vector containing a BAC vector sequence in the specific gene of a genomic gene of varicella-zoster virus; cells containing such a vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; a nucleic acid cassette containing the BAC vector sequence; and a multivalent vaccine. The above problems were solved by developing a process for producing a recombinant varicella-zoster virus, wherein the BAC vector sequence is inserted into a specific virus gene.

公开(公告)号：EP2471938A2

公开(公告)日：2012-07-04

申请号：EP12161534.8

申请日：2005-11-24

申请人： The Research Foundation for Microbial Diseases of Osaka University ,  National Institute of Biomedical Innovation

发明人： Mori, Yasuko ,  Somboonthum, Pranee ,  Yoshii, Hironori ,  Gomi, Yasuyuki ,  Takahashi, Michiaki ,  Yamanishi, Koichi

IPC分类号： C12N15/869 ,  A61K39/165 ,  A61K39/25 ,  A61K39/295 ,  A61P31/22 ,  A61P37/04 ,  C12N5/00 ,  C12N7/00

CPC分类号： A61K39/25 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16762 ,  C12N2760/18734 ,  C12N2800/204 ,  C12N2800/50 ,  C12N2820/55 ,  Y02A50/39 ,  Y02A50/394

摘要： The problems to be solved by the present invention are to provide: a recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing a recombinant varicella-zoster virus; a vector containing a BAC vector sequence in the specific gene of a genomic gene of varicella-zoster virus; cells containing such a vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; a nucleic acid cassette containing the BAC vector sequence; and a multivalent vaccine. The above problems were solved by developing a process for producing a recombinant varicella-zoster virus, wherein the BAC vector sequence is inserted into a specific virus gene.

公开(公告)号：EP2471937A3

公开(公告)日：2013-04-24

申请号：EP12161513.2

申请日：2005-11-24

申请人： The Research Foundation for Microbial Diseases of Osaka University ,  National Institute of Biomedical Innovation

发明人： Mori, Yasuko ,  Somboonthum, Pranee ,  Yoshii, Hironori ,  Gomi, Yasuyuki ,  Takahashi, Michiaki ,  Yamanishi, Koichi

IPC分类号： C12N15/869 ,  A61K39/165 ,  A61K39/25 ,  A61K39/295 ,  A61P31/22 ,  A61P37/04 ,  C12N5/00 ,  C12N7/00

CPC分类号： A61K39/25 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16762 ,  C12N2760/18734 ,  C12N2800/204 ,  C12N2800/50 ,  C12N2820/55 ,  Y02A50/39 ,  Y02A50/394

摘要： The problems to be solved by the present invention are to provide: a recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing a recombinant varicella-zoster virus; a vector containing a BAC vector sequence in the specific gene of a genomic gene of varicella-zoster virus; cells containing such a vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; a nucleic acid cassette containing the BAC vector sequence; and a multivalent vaccine. The above problems were solved by developing a process for producing a recombinant varicella-zoster virus, wherein the BAC vector sequence is inserted into a specific virus gene.

摘要翻译： 本发明要解决的问题是提供：重组水痘 - 带状疱疹病毒; 生产该工艺的方法; 含有重组水痘 - 带状疱疹病毒的药物组合物; 在水痘 - 带状疱疹病毒的基因组基因的特定基因中含有BAC载体序列的载体; 含有这种载体的细胞; 能够与水痘带状疱疹病毒基因组同源重组的片段; 含有BAC载体序列的核酸盒; 和多价疫苗。 通过开发生产重组水痘带状疱疹病毒的方法解决了上述问题，其中BAC载体序列被插入到特定的病毒基因中。

公开(公告)号：EP2471937A2

公开(公告)日：2012-07-04

申请号：EP12161513.2

申请日：2005-11-24

申请人： The Research Foundation for Microbial Diseases of Osaka University ,  National Institute of Biomedical Innovation

发明人： Mori, Yasuko ,  Somboonthum, Pranee ,  Yoshii, Hironori ,  Gomi, Yasuyuki ,  Takahashi, Michiaki ,  Yamanishi, Koichi

IPC分类号： C12N15/869 ,  A61K39/165 ,  A61K39/25 ,  A61K39/295 ,  A61P31/22 ,  A61P37/04 ,  C12N5/00 ,  C12N7/00

CPC分类号： A61K39/25 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16762 ,  C12N2760/18734 ,  C12N2800/204 ,  C12N2800/50 ,  C12N2820/55 ,  Y02A50/39 ,  Y02A50/394

摘要： The problems to be solved by the present invention are to provide: a recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing a recombinant varicella-zoster virus; a vector containing a BAC vector sequence in the specific gene of a genomic gene of varicella-zoster virus; cells containing such a vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; a nucleic acid cassette containing the BAC vector sequence; and a multivalent vaccine. The above problems were solved by developing a process for producing a recombinant varicella-zoster virus, wherein the BAC vector sequence is inserted into a specific virus gene.

公开(公告)号：EP2471936A2

公开(公告)日：2012-07-04

申请号：EP12161495.2

申请日：2005-11-24

申请人： The Research Foundation for Microbial Diseases of Osaka University ,  National Institute of Biomedical Innovation

发明人： Mori, Yasuko ,  Somboonthum, Pranee ,  Yoshii, Hironori ,  Gomi, Yasuyuki ,  Takahashi, Michiaki ,  Yamanishi, Koichi

IPC分类号： C12N15/869 ,  A61K39/165 ,  A61K39/25 ,  A61K39/295 ,  A61P31/22 ,  A61P37/04 ,  C12N5/00 ,  C12N7/00

CPC分类号： A61K39/25 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/70 ,  C12N15/86 ,  C12N2710/16734 ,  C12N2710/16743 ,  C12N2710/16762 ,  C12N2760/18734 ,  C12N2800/204 ,  C12N2800/50 ,  C12N2820/55 ,  Y02A50/39 ,  Y02A50/394

摘要： The problems to be solved by the present invention are to provide: a recombinant varicella-zoster virus; a process for producing the same; a pharmacological composition containing a recombinant varicella-zoster virus; a vector containing a BAC vector sequence in the specific gene of a genomic gene of varicella-zoster virus; cells containing such a vector; a fragment capable of homologous recombination with a genome of varicella-zoster virus; a nucleic acid cassette containing the BAC vector sequence; and a multivalent vaccine. The above problems were solved by developing a process for producing a recombinant varicella-zoster virus, wherein the BAC vector sequence is inserted into a specific virus gene.

摘要翻译： 本发明要解决的问题是提供：重组水痘带状疱疹病毒; 其制造方法; 含有重组水痘带状疱疹病毒的药物组合物; 在水痘带状疱疹病毒的基因组基因的特定基因中含有BAC载体序列的载体; 含有这种载体的细胞; 能够与水痘带状疱疹病毒基因组同源重组的片段; 含有BAC载体序列的核酸盒; 和多价疫苗。 通过开发生产重组水痘带状疱疹病毒的方法解决了上述问题，其中将BAC载体序列插入到特定病毒基因中。