专利检索 ap:("The Research Foundation for The State University of New York") AND inv:"YUROVSKY, Alisa" 第 1 页

1.

发明公开
MODIFIED PROTEIN ENCODING SEQUENCES HAVING INCREASED RARE HEXAMER CONTENT 审中-公开

公开(公告)号：EP3370766A1

公开(公告)日：2018-09-12

申请号：EP16863171.1

申请日：2016-11-07

申请人： The Research Foundation for The State University of New York

发明人： FUTCHER, Bruce , GARDIN, Justin , SKIENA, Steve , YUROVSKY, Alisa , WIMMER, Eckard , MUELLER, Steffen

IPC分类号： A61K39/12 , C12N7/04 , A61P31/12

CPC分类号： C12N7/00

摘要： This invention provides a modified protein encoding sequence containing nucleotide substitutions at multiple locations in the protein encoding sequence, wherein the substitutions introduce rare hexamers. These hexamers may be Frame Dependent, or depleted in only the reading frame, or Frame Independent, or depleted in all three frames. Modified protein encoding sequences of the present invention may include modified viruses useful for vaccines.