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公开(公告)号:EP1401490B1
公开(公告)日:2008-07-16
申请号:EP02731876.5
申请日:2002-05-21
发明人: COHEN, Stanley N., Dept. of Genetics School of Medicine , CARTER, Carol , GOFF, Arthur , EHRLICH, Lorna
IPC分类号: G01N33/50 , G01N33/569 , G01N33/68 , C07K14/16 , C07K14/47
CPC分类号: G01N33/502 , A61K38/1709 , C07K14/005 , C07K14/4702 , C07K2319/00 , C12N2740/16222 , G01N33/5008 , G01N33/56983 , G01N33/56988 , G01N33/6878 , G01N2333/16 , G01N2333/161 , G01N2500/02 , G01N2500/10 , G01N2500/20
摘要: The present invention provides methods for identifying peptides in a mammalian Tsg101 protein that binds to the PTAPP motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.
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公开(公告)号:EP1401490A1
公开(公告)日:2004-03-31
申请号:EP02731876.5
申请日:2002-05-21
发明人: COHEN, S.N.,Dept of Genetics School of Medicine , CARTER, Carol , GOFF, Arthur , EHRLICH, Lorna
CPC分类号: G01N33/502 , A61K38/1709 , C07K14/005 , C07K14/4702 , C07K2319/00 , C12N2740/16222 , G01N33/5008 , G01N33/56983 , G01N33/56988 , G01N33/6878 , G01N2333/16 , G01N2333/161 , G01N2500/02 , G01N2500/10 , G01N2500/20
摘要: The present invention provides methods for identifying peptides in a mammalian Tsg101 protein that binds to the PTAPP motif or L domain of human immunodeficiency virus type I (HIV-1). Such peptides can be used to inhibit Tsg101-HIV Gag binding, and is therefore effective in reducing HIV particle production. The invention also provides the peptides identified by the method of the invention and to method of using such peptides for treating HIV infection.
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