公开(公告)号：EP2656073A2

公开(公告)日：2013-10-30

申请号：EP11850401.8

申请日：2011-12-19

申请人： The Rockefeller University

发明人： RAVETCH, Jeffrey, V. ,  LI, Fubin

IPC分类号： G01N33/53 ,  A61K39/395

CPC分类号： C07K16/2878 ,  A61K38/177 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/2851 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/54 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/6863 ,  G01N2333/70535 ,  G01N2333/70578 ,  A61K31/00

摘要： The instant invention relates to agents (e.g., agonistic antibodies) able to stimulate the immune system of a mammalian animal and activate target-cell specific T lymphocyte responses. Such agents may be identified based on the ability to engage a receptor from the TNFR Superfamily and thereby mimic the natural ligand for the receptor from the TNFR Superfamily. Modified antibodies of this class display enhanced immunostimulatory activity and may be formulated and administered for the treatment of a disease or disorder.