公开(公告)号：EP3068442A1

公开(公告)日：2016-09-21

申请号：EP14862662.5

申请日：2014-11-14

申请人： The Royal Institution for the Advancement of Learning / McGill University

发明人： TRIFIRO, Mark ,  PALIOURAS, Miltiadis ,  ROCHE, Philip ,  DOTAN, Idit ,  BEITEL, Lenore ,  ALVARADO, Carlos ,  CARNEVALE, Matthew ,  MITMAKER, Elliot Jonathan

IPC分类号： A61K49/22 ,  A61K41/00 ,  A61K47/04 ,  A61K49/08 ,  A61K9/10 ,  C08J3/075 ,  C08J9/00 ,  C08K3/04 ,  C08L89/06

CPC分类号： A61K49/0095 ,  A01N59/00 ,  A61K33/44 ,  A61K41/0028 ,  A61K47/6851 ,  A61K47/6903 ,  A61K47/6905 ,  A61K49/0093 ,  A61K49/1803 ,  A61K49/1806 ,  A61K49/226 ,  A61L2/18 ,  B82Y5/00 ,  B82Y15/00 ,  C08J3/075 ,  C08J2389/00

摘要： There is provided a bionanofluid including a carbon-based nanomaterial substantially mono-dispersed in a fluid, wherein the carbon-based nanomaterial is surface modified with a polar group when the fluid is polar or with a non-polar group when the fluid is non-polar, and functionalized with a biological targeting moiety to allow specific association of the carbon-based nanomaterial to a targeted entity. Also provided is a hybrid bionanofluid including the bionanofluid, wherein the carbon-based nanomaterial is further modified with a hybrid nanoparticle which includes an alloy, transition metal, semi-conductor, semi- metal or polymer based nanoparticle with biological targeting moiety. A hydrogel, foam, cream, spray or dried product including the bionanofluid or hybrid bionanofluid is also provided. The bionanofluid or hybrid bionanofluid are useful in multimodal imaging (photo-luminescence, luminescence, photo-acoustic, MRI, ultrasound) and/or cellular targeting.

摘要翻译： 二元流体包括基本上单分散在流体中的碳基纳米材料。 当流体是非极性时，当流体是非极性的时，碳基纳米材料用极性基团进行表面改性，或者当流体是非极性时用非极性基团进行表面改性，并且用生物靶向部分官能化以允许碳基纳米材料与 一个有针对性的实体。 混合生物二亚胺流体包括生物纳米流体，碳纳米材料进一步用混合纳米颗粒进行改性，所述混合纳米颗粒包括具有生物靶向部分的合金，过渡金属，半导体，半金属或聚合物基纳米颗粒。 水凝胶，泡沫，奶油，喷雾或干燥产品包括生物纳米流体或混合生物二亚胺。 双流体或混合的二亚氨基流体可用于多模式成像（光致发光，发光，光声，MRI，超声）和/或细胞靶向。