利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

390 条记录 (耗时 0.022 秒)

    METHOD AND COMPOSITION FOR HYPERTHERMALLY TREATING CELLS
    6.
    发明授权
    METHOD AND COMPOSITION FOR HYPERTHERMALLY TREATING CELLS 有权
    超高温处理细胞的方法和组合物

    公开(公告)号：EP2736437B1

    公开(公告)日：2018-01-03

    申请号：EP12817427.3

    申请日：2012-07-05

    申请人： Peyman, Gholam, A.

    发明人： Peyman, Gholam, A.

    IPC分类号： A61B18/18 ,  A61B18/04 ,  A61K41/00 ,  A61K49/00 ,  A61K49/22 ,  A61P35/00

    CPC分类号： A61K41/0028 ,  A61K41/0052 ,  A61K49/0017 ,  A61K49/0058 ,  A61K49/0084 ,  A61K49/227

    摘要： A method and composition for hyperthermally diagnosing and monitoring treatment of cells in an animal with photoacoustic sound and nanoparticles. The heat (temperature) and photoacoustic sound wave production inside the target tissue is measured. The desired temperature is achieved using a laser and photoacoustic imaging technique. Hyperthermia treatment of tissue in a target site applies a heat source to kill cells without protein denaturation. The method introduces an encapsulated dye that is released at a selected temperature in the target site to indicate that a threshold temperature has been reached to hyperthermally treat the tissue. In one embodiment, the composition releases the dye at a temperature of 42° C. to 56° C., and preferably about 45° C. to 49° C. The composition which can be a liposome composition encapsulating the dye can be introduced to the bloodstream of the patient to flow through the target site.

    A METHOD FOR TREATING CANCER BASED ON METALLOFULLERENE MONOCRYSTALLINE NANOPARTICLES THAT SPECIFICALLY DISRUPT TUMOR BLOOD VESSELS
    7.
    发明公开
    A METHOD FOR TREATING CANCER BASED ON METALLOFULLERENE MONOCRYSTALLINE NANOPARTICLES THAT SPECIFICALLY DISRUPT TUMOR BLOOD VESSELS 审中-公开

    公开(公告)号：EP3130351A4

    公开(公告)日：2017-12-13

    申请号：EP14898405

    申请日：2014-07-29

    申请人： BEIJING FULLCAN BIO-TECHNOLOGY CO LTD

    发明人： WANG CHUNRU ,  ZHEN MINGMING ,  SHU CHUNYING ,  WANG TAISHAN ,  LI JIE ,  ZHANG GUOQIANG

    IPC分类号： A61K41/00 ,  A61P35/00

    CPC分类号： A61K41/0028 ,  A61K9/0019 ,  A61K41/00 ,  A61K51/0487 ,  A61K51/1251

    摘要： The present invention discloses use of metallofullerene monocrystalline nanoparticles for the preparation of tumor vascular disrupting agents. The monocrystalline nanoparticles are water-soluble metallofullerene nanoparticles with negative charges on their surfaces, the particle sizes thereof range from 50 to 250 nanometers; moreover, the nanomaterials are able to absorb outside radiation energy, and transform it into heat energy, the volumes thereof will rapidly expand when temperature reached phase transformation point. When treatment, metallofullerene monocrystalline nanoparticles are administrated to a tumor-bearing organism via injection; the metallofullerene monocrystalline nanoparticles reach tumor sites via blood circulation, and retain at the sites of pores and defects of tumors; the monocrystalline nanoparticles of metallofullerene accumulate heat and the temperature increases under the role of outside radiation energy, the volumes sharply expand when the temperature exceeds critical point of phase transition thereof, thereby to cause changes in the morphologies, structures or functions of endothelium cells of tumor vessels, further to starve the tumor cells.

    METHODS AND COMPOSITIONS FOR TUMOR VASCULATURE IMAGING AND TARGETED THERAPY
    10.
    发明公开
    METHODS AND COMPOSITIONS FOR TUMOR VASCULATURE IMAGING AND TARGETED THERAPY 审中-公开
    VERFAHREN UND ZUSAMMENSETZUNGEN ZUR GEZIELTENTUMORGEFÄSSBILDGEBUNGUNDERTHERAPIE

    公开(公告)号：EP3044590A1

    公开(公告)日：2016-07-20

    申请号：EP14844068.8

    申请日：2014-09-12

    申请人： The University of North Carolina at Chapel Hill

    发明人： DEMORE, Nancy ,  DAYTON, Paul ,  MUMPER, Russell ,  TSURUTA, James K.

    IPC分类号： G01N33/50 ,  C07K16/08 ,  A61K39/395

    CPC分类号： A61K49/221 ,  A61K41/0028 ,  A61K45/06 ,  A61K49/223 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/24

    摘要： Provided are compositions and methods for imaging one or more of tumor vasculature and tumor angiogenesis, wherein an imaging composition comprises anti-SFRP2 antibody operable linked to an imaging agent. Provided is a method of imaging tumor vasculature in an individual comprising administering to the individual a diagnostically effect of an imaging composition, and detecting the image resulting from the binding or complexing of the imaging composition with tumor vasculature. The imaging agent may also be used as a delivery vehicle to target one or more therapeutic agents to tumor vasculature and surrounding tumor tissue.

    摘要翻译： 提供用于成像肿瘤血管生成和肿瘤血管生成中的一种或多种的组合物和方法，其中成像组合物包含可操作地与成像剂连接的抗SFRP2抗体。 提供了一种对个体中的肿瘤脉管系统进行成像的方法，其包括向个体施用成像组合物的诊断效应，以及检测由成像组合物与肿瘤脉管系统结合或络合所产生的图像。 成像剂也可以用作递送载体，以将一种或多种治疗剂靶向肿瘤脉管系统和周围的肿瘤组织。