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1.发明公开CHIRAL COMPOUNDS OF VARYING CONFORMATIONAL RIGIDITY AND METHODS OF SYNTHESIS 审中-公开与不同构象刚性和合成方法的手性化合物
公开(公告)号：EP2753175A1
公开(公告)日：2014-07-16
申请号：EP12829942.7
申请日：2012-09-07
CPC分类号： C07K5/08 , A61K31/19 , A61K31/192 , A61K38/06 , A61K45/06 , C07B53/00 , C07B2200/07 , C07B2200/11 , C07C51/00 , C07C57/52 , C07C57/54 , C07C57/60 , C07C57/64 , C07D405/10 , C07D405/14 , C07K5/0205 , C07K5/0804 , G01N33/5008 , G01N2800/7028
摘要： Synthesis of compounds having varying degrees of conformational rigidity is obtained via a low cost, high yield and efficient synthetic reactions. The library of compounds is structurally diverse having at least one or more chiral centers and providing large numbers of compounds having building block diversity and substantial scaffold diversity. The compounds further provide a novel method for obtaining candidate therapeutic agents for prevention, treatment or diagnosis of diseases.
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公开(公告)号：EP2753175B1
公开(公告)日：2019-02-06
申请号：EP12829942.7
申请日：2012-09-07
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公开(公告)号：EP2771478A1
公开(公告)日：2014-09-03
申请号：EP12844007.0
申请日：2012-10-25
发明人： KODADEK, Thomas , GAO, Yu
IPC分类号： C12P21/06
CPC分类号： C07K7/06 , A61K38/08 , C07C51/363 , C07C231/02 , C07K1/042 , C07K1/047 , C07K5/06026 , C07K5/0806 , C07K14/001 , G01N33/6845 , C07C237/22 , C07C53/19
摘要： The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs),and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.
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公开(公告)号：EP2771478B1
公开(公告)日：2018-03-14
申请号：EP12844007.0
申请日：2012-10-25
发明人： KODADEK, Thomas , GAO, Yu
IPC分类号： C07K1/04 , C12P21/06 , C07C231/02 , A61K38/08 , C07K5/062 , C07K5/083 , C07C51/363 , G01N33/68 , C07K14/00 , C07K5/08 , C07K5/06
CPC分类号： C07K7/06 , A61K38/08 , C07C51/363 , C07C231/02 , C07K1/042 , C07K1/047 , C07K5/06026 , C07K5/0806 , C07K14/001 , G01N33/6845 , C07C237/22 , C07C53/19
摘要： The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others.
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