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1.发明授权
公开(公告)号：EP2359869B1
公开(公告)日：2018-12-26
申请号：EP10189725.4
申请日：2002-11-12
IPC分类号： A61K48/00 , C12N5/10 , C12N7/01 , C12N7/04 , C12N15/63 , C12N15/64 , C12N15/864 , C07H21/04 , C07K14/015 , C07K7/04 , C07K7/06
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N15/8645 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes is also provided.
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2.发明公开A method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby 有权Adenoassoziierten病毒（AAV）Cy.5 Sequenzen，diese enthaltende Vektoren und deren Verwendungen
公开(公告)号：EP2338900A1
公开(公告)日：2011-06-29
申请号：EP10178970.9
申请日：2002-11-12
IPC分类号： C07K14/015 , C12N15/864
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
摘要翻译： 提供了从组织或细胞获得的DNA样品中检测和分离AAV序列的方法。 本发明还提供了通过该方法鉴定的AAV序列，以及使用这些序列构建的载体。
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3.发明公开Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same and uses therefor 审中-公开腺相关病毒（AAV）血清型8，含有这样的序列及其用途矢量的序列
公开(公告)号：EP2359869A2
公开(公告)日：2011-08-24
申请号：EP10189725.4
申请日：2002-11-12
IPC分类号： A61K48/00 , C12N5/10 , C12N7/01 , C12N7/04 , C12N15/63 , C12N15/64 , C12N15/864 , C07H21/04 , C07K14/015 , C07K7/04 , C07K7/06
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N15/8645 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes is also provided.
摘要翻译： 提供一个8型腺相关病毒载体和宿主细胞和含合成序列的序列。 所以描述的是在生产rAAV颗粒的使用这样的宿主细胞和载体的方法。 因此治疗和免疫原性基因rAAV8介导的递送提供。
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4.发明公开Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same and uses therefor 审中-公开腺相关病毒（AAV）血清型8，含有这样的序列及其用途矢量的序列
公开(公告)号：EP2359869A3
公开(公告)日：2014-01-08
申请号：EP10189725.4
申请日：2002-11-12
IPC分类号： A61K48/00 , C12N5/10 , C12N7/01 , C12N7/04 , C12N15/63 , C12N15/64 , C12N15/864 , C07H21/04 , C07K14/015 , C07K7/04 , C07K7/06
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N15/8645 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes is also provided.
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5.发明授权Adeno-associated virus (AAV) Cy.5 sequences, vectors containing the same and uses thereof 有权Adenoassoziierten病毒（AAV）Cy.5 Sequenzen，diese enthaltende Vektoren und deren Verwendungen
公开(公告)号：EP2338900B1
公开(公告)日：2014-01-01
申请号：EP10178970.9
申请日：2002-11-12
IPC分类号： C07K14/015 , C12N15/864
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for dctecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
摘要翻译： 提供了从组织或细胞获得的DNA样品中切割和分离AAV序列的方法。 本发明还提供了通过该方法鉴定的AAV序列，以及使用这些序列构建的载体。
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6.发明公开
公开(公告)号：EP2341068A1
公开(公告)日：2011-07-06
申请号：EP10178940.2
申请日：2002-11-12
IPC分类号： C07K14/015 , C12N15/864
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for detecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
摘要翻译： 提供了从组织或细胞获得的DNA样品中检测和分离AAV序列的方法。 本发明还提供了通过该方法鉴定的AAV序列，以及使用这些序列构建的载体。
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7.发明授权Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor 有权腺相关病毒（AAV）血清型9序列，含有其的载体及其用途
公开(公告)号：EP2573170B1
公开(公告)日：2017-12-20
申请号：EP12163949.6
申请日：2002-11-12
IPC分类号： C12N7/00 , C12N7/01 , C12N15/85 , C12N15/86 , C12N15/864 , C07K14/015
CPC分类号： C07K14/005 , C12N15/86 , C12N2750/14122 , C12N2750/14143
摘要： Sequences of a serotype 9 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV9-mediated delivery of therapeutic and immunogenic genes is also provided.
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8.发明公开Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor 有权Adeno-assoziierte Virussequenzen vom Serotyp-9，sie enthaltende Vektoren und deren Verwendungen
公开(公告)号：EP2573170A3
公开(公告)日：2014-01-01
申请号：EP12163949.6
申请日：2002-11-12
IPC分类号： C12N7/00 , C12N7/01 , C12N15/85 , C12N15/86 , C12N15/864 , C07K14/015
CPC分类号： C07K14/005 , C12N15/86 , C12N2750/14122 , C12N2750/14143
摘要： Sequences of a serotype 9 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV9-mediated delivery of therapeutic and immunogenic genes is also provided.
摘要翻译： 提供血清型9腺相关病毒和含有这些序列的载体和宿主细胞的序列。 还描述了在生产rAAV颗粒中使用这种宿主细胞和载体的方法。 还提供rAAV9介导的治疗和免疫原性基因的递送。
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公开(公告)号：EP2341068B1
公开(公告)日：2013-09-25
申请号：EP10178940.2
申请日：2002-11-12
IPC分类号： C07K14/015 , C12N15/864
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for dctecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
摘要翻译： 提供了从组织或细胞获得的DNA样品中切割和分离AAV序列的方法。 本发明还提供了通过该方法鉴定的AAV序列，以及使用这些序列构建的载体。
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10.发明公开Adeno-associated virus (AAV) serotype 9 sequences, vectors containing same, and uses therefor 有权的血清型9，它们含有载体腺相关病毒序列和其用途
公开(公告)号：EP2573170A2
公开(公告)日：2013-03-27
申请号：EP12163949.6
申请日：2002-11-12
IPC分类号： C12N7/00 , C12N7/01 , C12N15/85 , C12N15/86 , C12N15/864 , C07K14/015
CPC分类号： C07K14/005 , C12N15/86 , C12N2750/14122 , C12N2750/14143
摘要： Sequences of a serotype 9 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV9-mediated delivery of therapeutic and immunogenic genes is also provided.
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