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公开(公告)号：EP2774985A1
公开(公告)日：2014-09-10
申请号：EP14162957.6
申请日：2009-10-29
IPC分类号： C12N7/00 , C12N15/861
CPC分类号： C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10341 , C12N2710/10342 , C12N2710/10343 , C12N2710/10345 , C12N2710/10352 , C12N2810/6018
摘要： A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
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2.发明授权Modified AAV rh48 capsids, compositions containing same and uses thereof 有权改性AAV衣壳rh48，其中包含这样的组合物及其用途
公开(公告)号：EP2359866B1
公开(公告)日：2013-07-17
申请号：EP10179330.5
申请日：2006-04-07
IPC分类号： A61K48/00 , C12N15/864 , A61K35/76 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
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3.发明公开Adeno-associated virus (AAV) serotype 8 sequences, vectors containing same and uses therefor 审中-公开腺相关病毒（AAV）血清型8，含有这样的序列及其用途矢量的序列
公开(公告)号：EP2359869A2
公开(公告)日：2011-08-24
申请号：EP10189725.4
申请日：2002-11-12
IPC分类号： A61K48/00 , C12N5/10 , C12N7/01 , C12N7/04 , C12N15/63 , C12N15/64 , C12N15/864 , C07H21/04 , C07K14/015 , C07K7/04 , C07K7/06
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N15/8645 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes is also provided.
摘要翻译： 提供一个8型腺相关病毒载体和宿主细胞和含合成序列的序列。 所以描述的是在生产rAAV颗粒的使用这样的宿主细胞和载体的方法。 因此治疗和免疫原性基因rAAV8介导的递送提供。
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4.发明公开Simian adenoviruses SAdV-36, -42.1, -42.2, AND -44 and uses thereof 有权丝棉SADV-36，-42.1，-42.2，-44和及其使用
公开(公告)号：EP2325298A2
公开(公告)日：2011-05-25
申请号：EP10186684.6
申请日：2009-03-03
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/761 , A61K39/145 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10371 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171
摘要： An adenovirus is disclosed, having a capsid comprising a hexon protein of SAdV-42.1 or an amino acid sequence at least about 99% identical thereto, or a hybrid hexon protein. The capsid encapsidates a heterologous nucleic acid molecule carrying a gene sequence operably linked to expression control sequences which direct transcription, translation, and/or expression in a host cell, and further encapsidates 5' and 3' adenovirus cis-elements necessary for replication and encapsidation.
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5.发明公开Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use 审中-公开猿猴腺病毒的核酸和氨基酸序列衍生的载体和使用方法。
公开(公告)号：EP2286841A1
公开(公告)日：2011-02-23
申请号：EP10178483.3
申请日：2002-11-20
发明人： Wilson, James M. , Gao, Guangping , Roy, Soumitra
IPC分类号： A61K47/42 , C07H21/00 , C07K14/075 , C12N7/00 , C12N15/33 , C12N15/861
CPC分类号： A61K39/235 , A61K39/00 , A61K48/00 , A61K2039/525 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10022 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10362 , C12N2710/20022 , C12N2740/16122 , C12N2740/17022 , C12N2750/14122 , C12N2760/14134 , C12N2760/16134 , C12N2760/20122 , C12N2830/002 , C12N2830/55
摘要： A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
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6.发明公开A Method of detecting and/or identifying adeno-associated virus (AVV) sequences and isolating novel sequences identified thereby 有权一种用于确定和腺相关病毒（AAV）序列的鉴定，以及用于分离由此确定了新的方法的序列
公开(公告)号：EP1310571A3
公开(公告)日：2003-08-13
申请号：EP02257826.4
申请日：2002-11-12
CPC分类号： C12N15/86 , A61K38/177 , A61K38/4846 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2750/14121 , C12N2750/14122 , C12N2750/14143 , C12N2750/14151 , C12N2750/14152 , C12N2750/14162 , C12N2750/14171 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12N2830/90 , C12Q1/701 , C12Q2600/158 , C12Y304/21022
摘要： A method for dctecting and isolating AAV sequences in a sample of DNA obtained from tissue or cells is provided. The invention further provides AAV sequences identified by this method, and vectors constructed using these sequences.
摘要翻译： 本发明提供一种用于从组织或细胞获得的DNA样品中dctecting和分离AAV序列的方法。 本发明提供了使用这些序列构建IDENTIFIED通过该方法此外AAV序列，和载体。
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7.发明授权
公开(公告)号：EP2359869B1
公开(公告)日：2018-12-26
申请号：EP10189725.4
申请日：2002-11-12
IPC分类号： A61K48/00 , C12N5/10 , C12N7/01 , C12N7/04 , C12N15/63 , C12N15/64 , C12N15/864 , C07H21/04 , C07K14/015 , C07K7/04 , C07K7/06
CPC分类号： C12N15/86 , A61K9/0019 , A61K35/761 , A61K38/177 , A61K38/45 , A61K38/4846 , A61K48/00 , C07K14/005 , C07K14/705 , C07K14/755 , C12N7/00 , C12N9/1018 , C12N9/644 , C12N15/8645 , C12N2750/14122 , C12N2750/14143 , C12N2750/14152 , C12N2830/008 , C12N2830/48 , C12N2830/85 , C12Y201/03003 , C12Y304/21021 , C12Y304/21022
摘要： Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles. rAAV8-mediated delivery of therapeutic and immunogenic genes is also provided.
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公开(公告)号：EP2774985B1
公开(公告)日：2016-12-14
申请号：EP14162957.6
申请日：2009-10-29
IPC分类号： C12N7/00 , C12N15/861
CPC分类号： C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10341 , C12N2710/10342 , C12N2710/10343 , C12N2710/10345 , C12N2710/10352 , C12N2810/6018
摘要： A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译： 重组载体包含猿猴腺病毒43,45,46,47,48,49或50个序列，以及在调节序列控制下的异源基因。 还公开了表达猿腺病毒43,45,46,47,48,49或50个基因的细胞系。 提供了使用载体和细胞系的方法。
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9.发明公开Simian adenoviruses SAdV-36, -42.1, -42.2, AND -44 and uses thereof 有权丝棉SADV-36，-42.1，-42.2，-44和及其使用
公开(公告)号：EP2325298A3
公开(公告)日：2012-08-29
申请号：EP10186684.6
申请日：2009-03-03
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/761 , A61K39/145 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10371 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171
摘要： An adenovirus is disclosed, having a capsid comprising a hexon protein of SAdV-42.1 or an amino acid sequence at least about 99% identical thereto, or a hybrid hexon protein. The capsid encapsidates a heterologous nucleic acid molecule carrying a gene sequence operably linked to expression control sequences which direct transcription, translation, and/or expression in a host cell, and further encapsidates 5' and 3' adenovirus cis-elements necessary for replication and encapsidation.
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10.发明公开Method of increasing the function of an AAV vector 有权Modifizierte AAV rh48 Kapside，Kompositionen die solche enthalten und dessen Verwendung
公开(公告)号：EP2359866A1
公开(公告)日：2011-08-24
申请号：EP10179330.5
申请日：2006-04-07
IPC分类号： A61K48/00 , C12N15/864 , A61K35/76 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
摘要翻译： 提供了一种校正所选AAV序列中的单体以提高所选AAV的包装产率，转导效率和/或基因转移效率的方法。 该方法涉及改变亲本AAV衣壳中的一个或多个单体以使单体与对准的功能AAV衣壳序列的相应位置中的氨基酸一致。
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