公开(公告)号：EP2954051A1

公开(公告)日：2015-12-16

申请号：EP14749120.3

申请日：2014-02-07

申请人： The Trustees Of The University Of Pennsylvania

发明人： CRONIN, Therese ,  BENNETT, Jean ,  VANDENBERGHE, Luk, E.

IPC分类号： C12N7/01

CPC分类号： C07K14/005 ,  A61K48/00 ,  C07K7/06 ,  C07K14/705 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2830/008

摘要： Described herein are capsid proteins and adeno-associated viruses capable of targeting various types of ocular cells including bipolar and horizontal cells. Also described herein are methods of treating various ocular disorders in a subject in need thereof by administering to the subject an effective concentration of a composition comprising the recombinant adeno-associated virus (AAV) of the invention.

公开(公告)号：EP2954051B1

公开(公告)日：2019-03-27

申请号：EP14749120.3

申请日：2014-02-07

申请人： The Trustees of The University of Pennsylvania

发明人： CRONIN, Therese ,  BENNETT, Jean ,  VANDENBERGHE, Luk, E.

IPC分类号： C12N7/01 ,  C12N15/864 ,  C07K14/015 ,  A61P27/02