-
1.发明公开
公开(公告)号：EP2547660A1
公开(公告)日：2013-01-23
申请号：EP11711417.3
申请日：2011-03-18
申请人： The United States Of America, As Represented By The Secretary, Department of Health and Human Services , The Arizona Board Of Regents On Behalf Of The University of Arizona
发明人： MIRANDA, Katrina M. , WINK, David A. , SALMON, Debra J. , BASUDHAR, Debashree , KEEFER, Larry K. , SAAVEDRA, Joseph E. , ANDREI, Daniela
IPC分类号： C07D231/16 , C07D261/12 , C07D327/04 , C07D417/12 , C07D513/04 , C07D515/04 , A61K31/15 , A61P35/00
CPC分类号： C07D261/12 , C07D231/16 , C07D327/04 , C07D417/12 , C07D513/04 , C07D515/04
摘要： Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof:(I) in which R
1 , R
2 , R
3 , and R
4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).-
2.发明授权
公开(公告)号：EP2547660B1
公开(公告)日：2015-01-07
申请号：EP11711417.3
申请日：2011-03-18
申请人： The United States Of America, As Represented By The Secretary, Department of Health and Human Services , The Arizona Board Of Regents On Behalf Of The University of Arizona
发明人： MIRANDA, Katrina M. , WINK, David A. , SALMON, Debra J. , BASUDHAR, Debashree , KEEFER, Larry K. , SAAVEDRA, Joseph E. , ANDREI, Daniela
IPC分类号： C07D231/16 , C07D261/12 , C07D327/04 , C07D417/12 , C07D513/04 , C07D515/04 , A61K31/15 , A61P35/00
CPC分类号： C07D261/12 , C07D231/16 , C07D327/04 , C07D417/12 , C07D513/04 , C07D515/04
-
3.发明公开HYBRID DIAZENIUMDIOLATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHOD OF TREATING CANCER 有权HYBRID氮烯鎓化合物，其药物组合物及其用于癌症治疗
公开(公告)号：EP2768824A2
公开(公告)日：2014-08-27
申请号：EP12841601.3
申请日：2012-10-18
IPC分类号： C07D403/10 , C07D241/04 , C07D237/26 , A61K31/496 , A61P35/00
CPC分类号： A61K31/655 , A61K31/69 , A61K31/704 , A61K45/06 , C07C291/02 , C07D237/30 , C07D237/32 , C07D295/28 , C07D403/10 , A61K2300/00
摘要： Disclosed are hybrid compounds that release both nitric oxide and a moiety that inhibits poly (ADP-ribose) polymerase (PARP), e.g., a compound or a pharmaceutically acceptable salt thereof of formula (I), wherein R
1-4 and m-p are as described herein. Also disclosed are pharmaceutical compositions and methods of use including treating cancer and enhancing the chemotherapeutic treatment of chemotherapeutic agents and high energy radiation.-
4.发明授权HYBRID DIAZENIUMDIOLATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND THEIR USE IN TREATING CANCER 有权HYBRID氮烯鎓化合物，其药物组合物及其用于癌症治疗
公开(公告)号：EP2768824B1
公开(公告)日：2016-12-07
申请号：EP12841601.3
申请日：2012-10-18
IPC分类号： C07D403/10 , C07D241/04 , C07D237/26 , A61K31/496 , A61P35/00
CPC分类号： A61K31/655 , A61K31/69 , A61K31/704 , A61K45/06 , C07C291/02 , C07D237/30 , C07D237/32 , C07D295/28 , C07D403/10 , A61K2300/00
-
-
-
搜索结果
4 条记录 (耗时 0.024 秒)
