公开(公告)号：EP2547660A1

公开(公告)日：2013-01-23

申请号：EP11711417.3

申请日：2011-03-18

申请人： The United States Of America, As Represented By The Secretary, Department of Health and Human Services ,  The Arizona Board Of Regents On Behalf Of The University of Arizona

发明人： MIRANDA, Katrina M. ,  WINK, David A. ,  SALMON, Debra J. ,  BASUDHAR, Debashree ,  KEEFER, Larry K. ,  SAAVEDRA, Joseph E. ,  ANDREI, Daniela

IPC分类号： C07D231/16 ,  C07D261/12 ,  C07D327/04 ,  C07D417/12 ,  C07D513/04 ,  C07D515/04 ,  A61K31/15 ,  A61P35/00

CPC分类号： C07D261/12 ,  C07D231/16 ,  C07D327/04 ,  C07D417/12 ,  C07D513/04 ,  C07D515/04

摘要： Disclosed is a compound of the formula (I) or a pharmaceutically acceptable salt thereof:(I) in which R
1 , R
2 , R
3 , and R
4 are defined herein and pharmaceutical compositions thereof. Further provided is a method of treating various disorders, such as a disorder selected from the group consisting of a cardiovascular disorder, cancer, chronic pain, alcohol dependence, and inflammation in a patient comprising administering an effective amount of a compound or pharmaceutically acceptable salt of formula (I).

公开(公告)号：EP2547660B1

公开(公告)日：2015-01-07

申请号：EP11711417.3

申请日：2011-03-18

申请人： The United States Of America, As Represented By The Secretary, Department of Health and Human Services ,  The Arizona Board Of Regents On Behalf Of The University of Arizona

发明人： MIRANDA, Katrina M. ,  WINK, David A. ,  SALMON, Debra J. ,  BASUDHAR, Debashree ,  KEEFER, Larry K. ,  SAAVEDRA, Joseph E. ,  ANDREI, Daniela

IPC分类号： C07D231/16 ,  C07D261/12 ,  C07D327/04 ,  C07D417/12 ,  C07D513/04 ,  C07D515/04 ,  A61K31/15 ,  A61P35/00

CPC分类号： C07D261/12 ,  C07D231/16 ,  C07D327/04 ,  C07D417/12 ,  C07D513/04 ,  C07D515/04

公开(公告)号：EP3215140A1

公开(公告)日：2017-09-13

申请号：EP15857037.4

申请日：2015-11-06

申请人： The Arizona Board of Regents On Behalf of the University of Arizona ,  The United States Of America as Represented by the Secretary, Department of Health an Human Service

发明人： MIRANDA, Katrina M. ,  WINK, David A. ,  BASUDHAR, Debashree

IPC分类号： A61K31/15

CPC分类号： A61K31/655 ,  A61K31/138 ,  A61K47/54 ,  A61K47/542 ,  A61K47/55

摘要： The present disclosure provides methods utilizing the diazeniumdiolate-based prodrugs for the treatment of cancer via various mechanisms and procedures. The disclosure also provides kits comprising the diazeniumdiolate-based prodrugs.

摘要翻译： 本公开提供了利用基于二醇二氮烯鎓的前药通过各种机制和程序来治疗癌症的方法。 本公开还提供了包含基于二醇二氮烯鎓的前药的试剂盒。 尽管在放射疗法，化学疗法和激素疗法等抗癌技术方面取得了重大进展，但在美国，癌症仍是继心脏病之后的第二大主要死亡原因。 大多数情况下，癌症采用高效药物进行化疗。