公开(公告)号：EP2480572B1

公开(公告)日：2019-01-30

申请号：EP10760878.8

申请日：2010-09-24

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services ,  University of Washington through its Center for Commercialization

发明人： MASCOLA, John, R. ,  WYATT, Richard ,  WU, Xueling ,  LI, Yuxing ,  HOGERKORP, Carl-Magnus ,  ROEDERER, Mario ,  YANG, Zhi-yong ,  NABEL, Gary ,  KWONG, Peter ,  ZHOU, Tongqing ,  CONNORS, Mark ,  OFEK, Gilad ,  SHAPIRO, Lawrence ,  ZHU, Jiang ,  SCHIEF, William R.

IPC分类号： C07K16/10

公开(公告)号：EP3525821A1

公开(公告)日：2019-08-21

申请号：EP17862065.4

申请日：2017-10-17

申请人： University of Maryland ,  The United States Of America, As Represented By The Secretary, Department Of Health And Human Services ,  Guenaga, Javier

发明人： GUENAGA, Javier ,  LI, Yuxing ,  STEINHARDT, James ,  MASCOLA, John, R.

IPC分类号： A61K39/395 ,  C07K16/46 ,  C07K16/10 ,  A61P31/18

公开(公告)号：EP2480572A2

公开(公告)日：2012-08-01

申请号：EP10760878.8

申请日：2010-09-24

申请人： THE UNITED STATES OF AMERICA, represented by the S ,  University Of Washington Through Its Center For Commercialization

发明人： MASCOLA, John, R. ,  WYATT, Richard ,  WU, Xueling ,  LI, Yuxing ,  HOGERKORP, Carl-Magnus ,  ROEDERER, Mario ,  YANG, Zhi-yong ,  NABEL, Gary ,  KWONG, Peter ,  ZHOU, Tongqing ,  CONNORS, Mark ,  OFEK, Gilad ,  SHAPIRO, Lawrence ,  ZHU, Jiang ,  SCHIEF, William R.

IPC分类号： C07K16/10

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C12N2740/10011 ,  C12N2740/16011 ,  C12N2740/16111

摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.