专利检索 ap:("The United States of America, as represented by The Secretary, Department of Health AND Human Services" OR "University of Washington through its Center for Commercialization") AND inv:"SHAPIRO, Lawrence" 第 1 页

1.

发明授权
NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 有权

公开(公告)号：EP2480572B1

公开(公告)日：2019-01-30

申请号：EP10760878.8

申请日：2010-09-24

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , University of Washington through its Center for Commercialization

发明人： MASCOLA, John, R. , WYATT, Richard , WU, Xueling , LI, Yuxing , HOGERKORP, Carl-Magnus , ROEDERER, Mario , YANG, Zhi-yong , NABEL, Gary , KWONG, Peter , ZHOU, Tongqing , CONNORS, Mark , OFEK, Gilad , SHAPIRO, Lawrence , ZHU, Jiang , SCHIEF, William R.

IPC分类号： C07K16/10

2.

发明公开
NEUTRALIZING ANTIBODIES TO HIV-1 GP41 AND THEIR USE 审中-公开

公开(公告)号：EP4011911A1

公开(公告)日：2022-06-15

申请号：EP21204045.5

申请日：2016-11-03

申请人： The United States of America as represented by The Secretary Department of Health and Human Services , The Trustees of Columbia University in the City of New York

发明人： KWONG, Peter , KWON, Young Do , GEORGIEV, Ivelin , OFEK, Gilad , ZHANG, Baoshan , MCKEE, Krisha , MACSOLA, John , CHUANG, Gwo-Yu , O'DELL, Sijy , GINDIN, Tatyana , SHAPIRO, Lawrence , BAILER, Robert , LOUDER, Mark , ASOKAN, Mangaiarkarasi , SCHWARTZ, Richard , COOPER, Jonathan , CARLTON, Kevin , BENDER, Michael , CONNORS, Mark , PEGU, Amarendra , KUELTZO, Lisa

IPC分类号： C07K16/10

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

3.

发明公开
NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 审中-公开
标题翻译：中和抗体对HIV-1及其用途

公开(公告)号：EP2480572A2

公开(公告)日：2012-08-01

申请号：EP10760878.8

申请日：2010-09-24

申请人： THE UNITED STATES OF AMERICA, represented by the S , University Of Washington Through Its Center For Commercialization

发明人： MASCOLA, John, R. , WYATT, Richard , WU, Xueling , LI, Yuxing , HOGERKORP, Carl-Magnus , ROEDERER, Mario , YANG, Zhi-yong , NABEL, Gary , KWONG, Peter , ZHOU, Tongqing , CONNORS, Mark , OFEK, Gilad , SHAPIRO, Lawrence , ZHU, Jiang , SCHIEF, William R.

IPC分类号： C07K16/10

CPC分类号： C07K16/1063 , A61K39/42 , A61K45/06 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2740/10011 , C12N2740/16011 , C12N2740/16111

摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.