公开(公告)号：EP2864764B1

公开(公告)日：2018-03-07

申请号：EP13806595.8

申请日：2013-06-05

申请人： The University of North Carolina at Chapel Hill

发明人： MELLORS, John Scott ,  RAMSEY, John Michael ,  BATZ, Nicholas George

IPC分类号： G01N27/447 ,  H01J49/16

CPC分类号： H01J49/165 ,  G01N27/4473 ,  G01N27/44743 ,  G01N27/44791 ,  G01N30/7266 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/26

摘要： Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.

公开(公告)号：EP2864764A1

公开(公告)日：2015-04-29

申请号：EP13806595.8

申请日：2013-06-05

申请人： The University Of North Carolina At Chapel Hill

发明人： MELLORS, John Scott ,  RAMSEY, John Michael ,  BATZ, Nicholas George

IPC分类号： G01N21/75

CPC分类号： H01J49/165 ,  G01N27/4473 ,  G01N27/44743 ,  G01N27/44791 ,  G01N30/7266 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/26

摘要： Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one ESI emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one ESI emitter thereby preferentially directing analyte molecules out of the at least one ESI emitter. The methods, systems and devices are particularly suitable for use with a mass spectrometer.

摘要翻译： 在具有至少一个流体样品分离流动通道的流体装置中产生差分轴向输送的方法，系统和装置以及与至少一个样品分离流动通道连通的至少一个ESI发射器。 响应于产生的差分轴向传输，包含在与样品分离通道连通的样品储存器中的至少一个目标分析物被选择性地输送到至少一个ESI发射体，同时抑制样品储存器中包含的污染物质向着 至少一个ESI发射体从而优先地将分析物分子导出至少一个ESI发射体。 方法，系统和装置特别适用于质谱仪。

公开(公告)号：EP3295160B1

公开(公告)日：2020-07-08

申请号：EP16724222.1

申请日：2016-05-10

申请人： The University of North Carolina at Chapel Hill

发明人： MELLORS, John Scott ,  REDMAN, Erin Anne ,  RAMSEY, John Michael

IPC分类号： G01N27/447 ,  G01N30/72

公开(公告)号：EP3365668A1

公开(公告)日：2018-08-29

申请号：EP16781227.0

申请日：2016-09-21

申请人： The University of North Carolina at Chapel Hill

发明人： MELLORS, John Scott ,  BLACK, William A. ,  RAMSEY, John Michael

IPC分类号： G01N27/447

CPC分类号： H01J49/0459 ,  G01N27/4473 ,  G01N27/44743 ,  G01N27/44791 ,  H01J49/165

摘要： Methods, systems and devices that provide fluid devices with at least one SPE bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a Mass Spectrometer. The fluid device can be configured to operate using independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods, systems and devices are particularly suitable for use with a mass spectrometer but optical or other electronic detectors may also be used with the fluidic devices.