公开(公告)号：EP2704565B1

公开(公告)日：2018-08-22

申请号：EP12727395.1

申请日：2012-05-04

申请人： The University Of Nottingham ,  Massachusetts Institute of Technology

发明人： WILLIAMS, Paul ,  ALEXANDER, Morgan Russell ,  DAVIES, Martyn Christopher ,  LANGER, Robert ,  ANDERSON, Daniel Griffith

IPC分类号： A01N25/10 ,  A01N37/12 ,  A01N37/20 ,  A61L27/34 ,  A61L27/50 ,  A61L29/14 ,  A61L29/16 ,  A61L31/10 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F222/10 ,  C08F220/56

CPC分类号： A61L29/16 ,  A01N37/12 ,  A01N37/20 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F220/56 ,  C08F222/1006 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26 ,  A01N25/10 ,  A01N25/34

摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(=0)-0-]n, R (I) [H2C═CR′—C(=0)-NH—]n R (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.

公开(公告)号：EP2704565A2

公开(公告)日：2014-03-12

申请号：EP12727395.1

申请日：2012-05-04

申请人： The University Of Nottingham ,  Massachusetts Institute Of Technology

发明人： WILLIAMS, Paul ,  ALEXANDER, Morgan Russell ,  DAVIES, Martyn Christopher ,  LANGER, Robert ,  ANDERSON, Daniel Griffith

IPC分类号： A01N25/10 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F222/10

CPC分类号： A61L29/16 ,  A01N37/12 ,  A01N37/20 ,  A61L27/34 ,  A61L27/50 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C08F220/18 ,  C08F220/22 ,  C08F220/24 ,  C08F220/56 ,  C08F222/1006 ,  C08L33/08 ,  C08L33/10 ,  C08L33/26 ,  A01N25/10 ,  A01N25/34

摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR  (I) [H2C═CR′—C(═O)—NH—]nR  (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.

公开(公告)号：EP3191582A1

公开(公告)日：2017-07-19

申请号：EP15771998.0

申请日：2015-09-11

申请人： The University Of Nottingham

发明人： ALEXANDER, Morgan Russell ,  DENNING, Chris ,  YOUNG, Lorraine ,  CELIZ, Adam ,  SMITH, James ,  DAVIES, Martyn Christopher ,  PATEL, Asha

IPC分类号： C12N5/00 ,  C12N5/077

CPC分类号： C12N5/0068 ,  C08F20/18 ,  C08F20/58 ,  C08F2800/20 ,  C08L33/08 ,  C08L33/26 ,  C08L2203/02 ,  C08L2205/025 ,  C08L2205/03 ,  C09D5/03 ,  C09D133/08 ,  C09D133/26 ,  C12M41/12 ,  C12M47/02 ,  C12N5/0696 ,  C12N2506/02 ,  C12N2506/45 ,  C12N2523/00 ,  C12N2533/30

摘要： The invention provides a substrate for cell culture comprising a polymer, wherein the polymer comprises -a homopolymer formed from a monomer of formula (Ia) or (Ib); -a copolymer formed from one or more monomers of formula (Ia) and/or (Ib); or -a copolymer formed from one or more monomers of formula (Ia) and/or (Ib), and comprising HEMA; wherein formula (Ia) comprises: (Formula (Ia)) wherein R1 is a C8-C12 straight or branched chain alkyl or alkenyl group, for example a C8-C10 straight or branched chain alkyl group, which may optionally be substituted; and R2 is selected from H and C1-4 alkyl; and wherein formula (Ib) comprises: (Formula (Ib)) wherein R3 is a 6-12 membered ring, for example a 6-8 membered ring, which is a cycloalkyl, cycloheteroalkyl, aryl or heteroaryl group, and which may optionally be substituted; L is a divalent linker group selected from -NH-, -CH2-, and -O-; R4 is a C1-8 organic group, for example a C1-C6 organic group, wherein this group comprises at least one moiety selected from C=O, NH, NH2, COOH, and C=C.

摘要翻译： 本发明提供了用于细胞培养的包含聚合物的底物，其中所述聚合物包含由式（Ia）或（Ib）的单体形成的均聚物; - 由一种或多种式（Ia）和/或（Ib）的单体形成的共聚物; 或 - 由一种或多种式（Ia）和/或（Ib）的单体形成并且包含HEMA的共聚物; 其中式（Ia）包含：（式（Ia））其中R 1是C 8 -C 12直链或支链烷基或链烯基，例如C 8 -C 10直链或支链烷基，其可以任选被取代; 且R2选自H和C1-4烷基; 并且其中式（Ib）包含：其中R 3为6-12元环例如6-8元环的式（Ib）：其为式（Ib）的基团，其为环烷基，环杂烷基，芳基或杂芳基， 取代; L是选自-NH - ， - CH 2 - 和-O-的二价连接基团; R 4是C 1-8有机基团，例如C 1 -C 6有机基团，其中该基团包含选自C = O，NH，NH 2，COOH和C = C的至少一个部分。