公开(公告)号：EP3351632A1

公开(公告)日：2018-07-25

申请号：EP16845971.7

申请日：2016-09-16

申请人： The University Of Tokyo ,  Genedesign, Inc.

发明人： IBA, Hideo ,  HARAGUCHI, Takeshi ,  NANKAI, Hirokazu ,  SATO, Hideaki

IPC分类号： C12N15/113 ,  A61K31/712 ,  A61K31/713 ,  A61K48/00 ,  A61P31/12 ,  A61P35/00

CPC分类号： C12N15/113 ,  A61K31/712 ,  A61K31/713 ,  A61K48/00 ,  C12N2310/141 ,  C12N2310/3231

摘要： The present invention pertains to the improvement of a miRNA inhibitor (a synthesized Tough Decoy (S-TuD)). The present invention provides a miRNA inhibitory complex including RNA or an analog thereof, wherein the RNA inhibitory complex includes at least one double-stranded structure and a miRNA binding sequence, each of two strands of the miRNA binding sequence being bound to two strands of at least one end of the double-stranded structure, and the miRNA inhibitory complex further includes at least one crosslinked nucleic acid.

公开(公告)号：EP3238727A1

公开(公告)日：2017-11-01

申请号：EP15872274.4

申请日：2015-12-24

申请人： National Institutes of Biomedical Innovation, Health and Nutrition ,  Genedesign, Inc.

发明人： ISHII, Ken ,  AOSHI, Taiki ,  SATO, Hideaki

IPC分类号： A61K31/7088 ,  A61K9/127 ,  A61P37/04 ,  C12N15/09

CPC分类号： C12N15/117 ,  A61K9/127 ,  A61K31/7088 ,  C12N15/09 ,  C12N2310/17 ,  C12N2310/315

摘要： Provided are non-aggregating immunostimulatory oligonucleotides. The present invention also provides a delivery agent for an immunostimulatory-oligonucleotide nucleic acid medicine, said delivery agent including a nucleic acid that contains a phosphorothioated nucleotide. According to another aspect, the present invention further provides an oligonucleotide including a bioactive core, and a nucleic acid that contains a phosphorothioated nucleotide. The present invention yet further provides an immunostimulator including the bioactive core of a type A/D, type B/K, or type C immunostimulatory oligonucleotide.

摘要翻译： 提供非聚集性免疫刺激性寡核苷酸。 本发明还提供用于免疫刺激寡核苷酸核酸药物的递送剂，所述递送剂包含含有硫代磷酸化核苷酸的核酸。 根据另一方面，本发明进一步提供了包含生物活性核心的寡核苷酸和含有硫代磷酸化核苷酸的核酸。 本发明还提供了包含A / D型，B / K型或C型免疫刺激性寡核苷酸的生物活性核的免疫刺激剂。

公开(公告)号：EP3597197A1

公开(公告)日：2020-01-22

申请号：EP18767416.3

申请日：2018-03-16

申请人： National University Corporation Chiba University ,  Genedesign, Inc. ,  NOF Corporation

发明人： IBA, Hideo ,  HARAGUCHI, Takeshi ,  NANKAI, Hirokazu ,  SATO, Hideaki

IPC分类号： A61K31/7105 ,  A61K9/14 ,  A61K31/713 ,  A61P1/00 ,  A61P11/00 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C12N15/00

摘要： Provided is a novel technique for treating cancer using structurally-reinforced S-TuD. Provided are: a composition for the prevention or treatment of tumors, said composition comprising an miRNA inhibitory complex including RNA of analog thereof; and a method for preventing or treating tumors using said composition. The miRNA inhibitory complex preferably includes at least one double-stranded structure and an miRNA-binding sequence. Two strands of the miRNA binding sequence preferably bind individually to two strands on at least one end of the double-stranded structure. According to some of the aspects of the present invention, there is provided a delivery system for delivering such an miRNA inhibitory complex.