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1.发明公开
公开(公告)号：EP3508510A1
公开(公告)日：2019-07-10
申请号：EP18199187.8
申请日：2018-10-08
IPC分类号： C08G18/48 , A61L29/14 , C08G18/66 , C08G18/67 , C08G18/75 , C08G18/83 , C08G18/32 , C08G18/08 , A61L27/34 , A61L27/18 , A61L29/06 , A61L29/16 , A61L31/06 , A61L15/26 , A61L31/16 , A61L15/46 , A61L17/04 , C07C319/20 , C07C323/25 , C08L75/04 , C07C323/52
摘要： In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.
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2.发明授权POLYMERIC STRUCTURES CONTAINING STRAINED CYCLOALKYNE FUNCTIONALITY FOR POST-FABRICATION AZIDEALKYNE CYCLOADDITION FUNCTIONALIZATION 有权聚合酶联免疫吸附测定仪CYCLOALKYNFUNKTIONALITÄTFÜRAZIDALKYNCYCLOADDITIONSFUNKTIONALISIERUNG NACH DEM HERSTELLUNGSPROZESS
公开(公告)号：EP2879665B1
公开(公告)日：2017-03-29
申请号：EP13824926.3
申请日：2013-07-31
发明人： BECKER, Matthew L , ZHENG, Jukuan
CPC分类号： C08G63/91 , A61L27/14 , A61L27/38 , A61L2400/12 , C07C271/34 , C08G63/6852 , C08G63/912 , C08G69/10 , C08G69/48 , C08G85/004 , D01F6/60 , D01F6/625 , D06M11/58
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3.发明公开
公开(公告)号：EP2879665A1
公开(公告)日：2015-06-10
申请号：EP13824926.3
申请日：2013-07-31
发明人： BECKER, Matthew L , ZHENG, Jukuan
CPC分类号： C08G63/91 , A61L27/14 , A61L27/38 , A61L2400/12 , C07C271/34 , C08G63/6852 , C08G63/912 , C08G69/10 , C08G69/48 , C08G85/004 , D01F6/60 , D01F6/625 , D06M11/58
摘要： A method of creating biocompatible polymeric structures includes the steps of: providing a biocompatible polymer including a strained cycloalkyne end group; forming a polymeric structure from the biocompatible polymer such that the strained cycloalkyne end group remains on the biocompatible polymer; providing an azide tethered molecule; and, after forming the polymeric structure, reacting the azide tethered molecule with the cycloalkyne in an azide alkyne cycloaddition reaction to further functionalize the polymeric structure.
摘要翻译： 产生生物相容性聚合物结构的方法包括以下步骤：提供包括应变环炔末端基团的生物相容性聚合物; 由生物相容性聚合物形成聚合物结构，使得应变的环炔末端基团保留在生物相容性聚合物上; 提供叠氮系留分子; 并且在形成聚合物结构之后，使叠氮化物栓系分子与环炔烃在叠氮化物炔环加成反应中反应以进一步官能化聚合物结构。
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