公开(公告)号：EP3508510A1

公开(公告)日：2019-07-10

申请号：EP18199187.8

申请日：2018-10-08

申请人： The University of Akron ,  Cook Medical Technologies LLC

发明人： BECKER, Matthew L ,  ZANDER, Zachary K ,  CHAMBERS, Sean ,  CHIARI, Alec ,  McROY, Will

IPC分类号： C08G18/48 ,  A61L29/14 ,  C08G18/66 ,  C08G18/67 ,  C08G18/75 ,  C08G18/83 ,  C08G18/32 ,  C08G18/08 ,  A61L27/34 ,  A61L27/18 ,  A61L29/06 ,  A61L29/16 ,  A61L31/06 ,  A61L15/26 ,  A61L31/16 ,  A61L15/46 ,  A61L17/04 ,  C07C319/20 ,  C07C323/25 ,  C08L75/04 ,  C07C323/52

摘要： In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.