MOLECULAR SENSOR PREPARATIONS AND USES THEREOF
    4.
    发明公开
    MOLECULAR SENSOR PREPARATIONS AND USES THEREOF 审中-公开
    MOERKULARSENSORZUBEREITUNGEN UND VERWENDUNGEN DAVON

    公开(公告)号:EP3102303A1

    公开(公告)日:2016-12-14

    申请号:EP15701831.8

    申请日:2015-01-16

    IPC分类号: B01D15/38 B01J20/26 B01J20/30

    摘要: The present invention relates to a method of preparing a molecular sensor that is specific for a target molecule having a saccharide or peptide region. The method comprises using the target molecule as a template and incubating the template with a receptor to form a template-receptor complex. A molecular scaffold is formed on a surface around the template-receptor complex such that the receptor and at least a portion of the template are embedded in the scaffold, and the template is removed to produce a cavity defined by the scaffold, such that the cavity is complementary to at least a portion of the saccharide or peptide region of the target molecule.

    摘要翻译: 本发明涉及一种制备对具有糖或肽区域的靶分子具有特异性的分子传感器的方法。 该方法包括使用靶分子作为模板,并用受体孵育模板以形成模板 - 受体复合物。 在模板 - 受体复合物周围的表面上形成分子支架,使得受体和模板的至少一部分嵌入支架中,并且去除模板以产生由支架限定的空腔,使得腔 与靶分子的至少一部分糖或肽区互补。