-
公开(公告)号：EP1643983B1
公开(公告)日：2010-05-05
申请号：EP04776717.3
申请日：2004-06-18
IPC分类号： A61K31/133 , A61P9/00
CPC分类号： A61K31/661 , A61K31/00 , A61K31/133 , A61K31/137 , Y02A50/385
摘要： Agonist of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial sphingosine-1-phosphate receptor agonists are employed in methods of treating a mammal for vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. The sphingosine-1-phosphate receptor agonists can be used for the manufacture of a medicament for treating vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels.
-
公开(公告)号：EP1643983A2
公开(公告)日：2006-04-12
申请号：EP04776717.3
申请日：2004-06-18
IPC分类号： A61K31/133 , A61P9/00
CPC分类号： A61K31/661 , A61K31/00 , A61K31/133 , A61K31/137 , Y02A50/385
摘要： Agonist of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial sphingosine-1-phosphate receptor agonists are employed in methods of treating a mammal for vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. The sphingosine-1-phosphate receptor agonists can be used for the manufacture of a medicament for treating vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels.
-
搜索结果
2 条记录 (耗时 0.009 秒)
