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    SYSTEMS AND METHODS FOR CONTINUOUS MANUFACTURING OF LIPOSOMAL DRUG FORMULATIONS
    2.
    发明公开
    SYSTEMS AND METHODS FOR CONTINUOUS MANUFACTURING OF LIPOSOMAL DRUG FORMULATIONS 审中-公开
    用于连续制造脂质体药物制剂的系统和方法

    公开(公告)号：EP3271057A1

    公开(公告)日：2018-01-24

    申请号：EP16714141.5

    申请日：2016-03-18

    申请人： The University of Connecticut

    发明人： COSTA, Antonio ,  BURGESS, Diane, J.

    IPC分类号： B01F3/08 ,  B01F5/04 ,  A61K9/127 ,  B01J13/04

    CPC分类号： A61K9/1277 ,  B01F3/0807 ,  B01F5/045 ,  B01F15/00149 ,  B01F2215/0032 ,  B01J13/04

    摘要： The present disclosure provides systems and methods for the continuous production of liposomes. An example method includes (a) mixing a solution of lipid and organic solvent from one or more containers to create an organic solvent-lipid solution, (b) providing the organic solvent-lipid solution to a first inlet of an injection port at a first flow rate, wherein the first inlet is in fluid communication with a first conduit, (c) providing an aqueous solution to a second inlet of the injection port at a second flow rate, wherein the second inlet is in fluid communication with a second conduit, wherein the first conduit is positioned concentrically within the second conduit at an outlet of the injection port, and wherein the first conduit extends through the outlet of the injection port, and (d) mixing the organic lipid solution and the aqueous solution to create a plurality of liposomes.

    MATERIALS AND DESIGN FOR AN ELECTROCATALYTIC DEVICE AND METHOD WHICH PRODUCES CARBON NANOTUBES AND HYDROCARBON TRANSPORTATION FUELS
    3.
    发明公开
    MATERIALS AND DESIGN FOR AN ELECTROCATALYTIC DEVICE AND METHOD WHICH PRODUCES CARBON NANOTUBES AND HYDROCARBON TRANSPORTATION FUELS 有权
    方法FÜRDIE HERSTELLUNG VON KOHLENSTOFF-NANORÖHREN

    公开(公告)号：EP2691560A2

    公开(公告)日：2014-02-05

    申请号：EP12719112.0

    申请日：2012-03-26

    申请人： Honda Motor Co., Ltd. ,  The University of Connecticut

    发明人： SUIB, Steven, L. ,  BROOKS, Christopher, James ,  FRUEH, Samuel ,  HU, Boxun ,  KREIDLER, Eric, Rolland

    IPC分类号： C25B3/00 ,  C25B3/04 ,  C01B31/02 ,  B82Y40/00

    CPC分类号： C25B1/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/16 ,  C25B3/04 ,  C25B9/08 ,  Y02P20/142

    摘要： The present teachings are directed toward an electrocatalytic cell including a barrier, having at least a first side and a second side opposite the first side, comprising a material permeable to oxygen ions and impermeable to at least C0
    2 , CO, H,
    2 H
    2 0 and hydrocarbons, an electrical power supply in communication with the barrier, a catalyst adjacent the first side of the barrier, a supply of feedstock components in communication with the first side of the barrier, a supply of a carrier gas component in communication with the second side of the barrier; wherein the feedstock components contact the catalyst and react to form hydrocarbon- containing components and oxygen-containing components, and the electrical power supply biases the barrier to thereby conduct oxygen ions from the first side to the second side. Also presented are a device and methods for producing carbon nanotubes.

    摘要翻译： 本教导涉及包括阻挡物的电催化电池，其具有至少第一侧和与第一侧相对的第二侧，包括可渗透氧离子的材料，并且至少不能透过至少CO 2，CO，H 2，H 2 O和烃， 与屏障连通的电源，与屏障的第一侧相邻的催化剂，与阻挡层的第一侧连通的原料组分的供应，与第二侧连通的载气组分的供应 屏障; 其中所述原料组分与所述催化剂接触并反应以形成含烃组分和含氧组分，并且所述电源对所述屏障施加偏压，从而将氧离子从所述第一侧传导至所述第二侧。 还提出了用于生产碳纳米管的装置和方法。

    METHODS OF INHIBITING VASCULAR PERMEABILITY AND APOPTOSIS
    6.
    发明授权
    METHODS OF INHIBITING VASCULAR PERMEABILITY AND APOPTOSIS 有权
    一种抑制血管通透性，及细胞凋亡

    公开(公告)号：EP1643983B1

    公开(公告)日：2010-05-05

    申请号：EP04776717.3

    申请日：2004-06-18

    申请人： The University of Connecticut

    发明人： HLA, Timothy ,  SANCHEZ, Teresa ,  PAIK, Ji-Hye ,  CLAFFEY, Kevin, P.

    IPC分类号： A61K31/133 ,  A61P9/00

    CPC分类号： A61K31/661 ,  A61K31/00 ,  A61K31/133 ,  A61K31/137 ,  Y02A50/385

    摘要： Agonist of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial sphingosine-1-phosphate receptor agonists are employed in methods of treating a mammal for vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels. The sphingosine-1-phosphate receptor agonists can be used for the manufacture of a medicament for treating vascular permeability disorders and unwanted vascular endothelial cell apoptosis, and for the growth of new blood vessels.

    Novel anandamide amidase inhibitors as analgesic agents
    7.
    发明公开
    Novel anandamide amidase inhibitors as analgesic agents 失效
    Anandamid-Amidaseinhibitoren als Analgetika

    公开(公告)号：EP1775286A1

    公开(公告)日：2007-04-18

    申请号：EP06024572.7

    申请日：1997-05-30

    申请人： The University of Connecticut

    发明人： Makriyannis, Alexandros ,  Lin, Sonyan ,  Hill, William Adam

    IPC分类号： C07D207/46 ,  A61K31/165 ,  A61K31/10 ,  A61K31/40 ,  C07C239/22

    CPC分类号： A61K31/4015 ,  A61K31/185 ,  A61K31/255 ,  C07D207/46

    摘要： Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. The disclosed method and novel compounds can be used to reduce pain in an individual or animal suffering from pain, reducing nausea in an individual undergoing chemotherapy, for example cancer chemotherapy, suppressing appetite in an individual, reducing intraocular pressure in the eye of an individual or animal suffering from glaucoma and suppressing the immune system in an individual with an organ transplant.

    摘要翻译： 公开了一种抑制个体或动物中的酰胺酰胺酶和新型氨基酰胺酰胺酶抑制剂的方法。 所公开的方法和新化合物可用于减轻患有疼痛的个体或动物的疼痛，减少经历化学疗法的个体的恶心，例如癌症化疗，抑制个体的食欲，降低个体眼中的眼内压或 患有青光眼的动物和用器官移植抑制个体的免疫系统。

    ARTIFICIAL TISSUE SYSTEMS AND USES THEREOF
    9.
    发明公开
    ARTIFICIAL TISSUE SYSTEMS AND USES THEREOF 有权
    人工组织系统和用途保

    公开(公告)号：EP1689321A2

    公开(公告)日：2006-08-16

    申请号：EP04816945.2

    申请日：2004-11-05

    申请人： The University of Connecticut

    发明人： KLUEH, Ulrike, W. ,  DORSKY, David, I. ,  KREUTZER, Donald, L.

    IPC分类号： A61F2/02 ,  A61F2/06 ,  C12N15/09 ,  C12N15/63 ,  C12N5/00

    CPC分类号： A61B5/686 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61K35/12 ,  A61L27/38 ,  C12N5/0062

    摘要： An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of diagnostic and testing related thereto. The ATS, among other things, induce better integration, function, and extended lifespan of the devices at the site of implantation. The ATS includes cells, such as naturally occurring, engineered, and/or artificial cells; matrices such as natural, engineered, artificial and/or hybrid matrices; tissue response modifiers (TRM); and/or cell response modifiers (CRM). The specific composition of the ATS is based on the nature of the tissue in which ATS-device combination is implanted and the nature of the implant device, as well as the required function and lifespan of the implanted device. Additionally, the ATS, as well as ATSdevice combinations can be utilized in vitro to aid in the design of improved ATS, devices and ATS-device combinations for in \>ivo uses.