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    METHODS AND MODIFIED CELLS FOR THE TREATMENT OF CANCER
    1.
    发明公开
    METHODS AND MODIFIED CELLS FOR THE TREATMENT OF CANCER 有权
    方法和修改的细胞治疗癌症

    公开(公告)号：EP1069908A2

    公开(公告)日：2001-01-24

    申请号：EP99919803.9

    申请日：1999-04-08

    申请人： The University of North Carolina at Chapel Hill

    发明人： MacDONALD, Gene, H. ,  MARTIN, Brian, K. ,  JOHNSTON, Robert, E. ,  TING, Jenny, P.-Y.

    IPC分类号： A61K39/00 ,  C12N15/86 ,  C12N7/01 ,  C12N5/10

    CPC分类号： A61K39/0011 ,  A61K48/00 ,  A61K2039/5254 ,  A61K2039/5258

    摘要： The present invention provides methods of preventing and/or treating cancers (including tumors). In one preferred embodiment, the invention is practiced to induce regression of an existing cancer or tumor and/or to prevent metastasis and/or to prevent growth of metastatic nodules. In other preferred embodiments, the invention may be used as a prophylaxis to prevent the development of primary cancers through a childhood or adult vaccination program against specific tumor antigens for cancers with high incidences. In an alternate preferred embodiment, the present invention provides methods of establishing an immune response against a universal artificial tumor antigen through a childhood or adult vaccine program, thus providing a long-term immune response that can be utilized at any point to treat any cancer which develops later in life. The present invention also provides cancer and tumor cells stably expressing an artificial antigen, preferably an artificial cell-surface antigen.

    摘要翻译： 本发明提供了预防和/或治疗癌症（包括肿瘤）的方法。 在一个优选的实施方案中，实施本发明以诱导现有癌症或肿瘤的消退和/或预防转移和/或防止转移性结节的生长。 在其他优选的实施方案中，本发明可用作预防，以通过针对高发病率癌症的特定肿瘤抗原的童年或成人接种计划来预防原发性癌症的发展。 在另一个优选的实施方案中，本发明提供了通过童年或成人疫苗程序建立针对通用人造肿瘤抗原的免疫应答的方法，从而提供了可在任何时间点用于治疗任何癌症的长期免疫应答， 后来在人生​​中发展。 本发明还提供了稳定表达人工抗原的癌症和肿瘤细胞，优选人造细胞表面抗原。