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公开(公告)号：EP2062246A2
公开(公告)日：2009-05-27
申请号：EP07874444.8
申请日：2007-08-16
IPC分类号： G09B19/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/21 , A61K2039/5254 , A61K2039/5258 , C07K14/005 , C07K2319/85 , C12N15/86 , C12N2740/15022 , C12N2740/15023 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2770/36143 , C12N2810/6054
摘要： The present invention provides novel self-replicating and self-propagating chimeric viral vectors and chimeric virus particles comprising a modified genome of a carrier RNA virus packaged within structural proteins of a second virus. Also provided are pharmaceutical formulations comprising the chimeric viral vectors and virus particles and methods of inducing an immune response by administration of the chimeric viral vectors and virus particles or nucleic acids (e.g., DNA and/or RNA) encoding the same to a subject.
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公开(公告)号：EP1012295A1
公开(公告)日：2000-06-28
申请号：EP96916547.1
申请日：1996-05-21
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , The Government of The United States of America,represented by The Secretary of the Army
发明人： JOHNSTON, Robert, E. , DAVIS, Nancy, L. , SMITH, Jonathan, F. , PUSHKO, Peter , PARKER, Michael , LUDWIG, George
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least alphavirus one structural protein not encoded by the first helper RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell. Preferably, the helper cell also includes a replicon RNA encoding an alphavirus packaging sequence and an inserted heterogeneous RNA.
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公开(公告)号：EP1069908A2
公开(公告)日：2001-01-24
申请号：EP99919803.9
申请日：1999-04-08
CPC分类号： A61K39/0011 , A61K48/00 , A61K2039/5254 , A61K2039/5258
摘要： The present invention provides methods of preventing and/or treating cancers (including tumors). In one preferred embodiment, the invention is practiced to induce regression of an existing cancer or tumor and/or to prevent metastasis and/or to prevent growth of metastatic nodules. In other preferred embodiments, the invention may be used as a prophylaxis to prevent the development of primary cancers through a childhood or adult vaccination program against specific tumor antigens for cancers with high incidences. In an alternate preferred embodiment, the present invention provides methods of establishing an immune response against a universal artificial tumor antigen through a childhood or adult vaccine program, thus providing a long-term immune response that can be utilized at any point to treat any cancer which develops later in life. The present invention also provides cancer and tumor cells stably expressing an artificial antigen, preferably an artificial cell-surface antigen.
摘要翻译： 本发明提供了预防和/或治疗癌症（包括肿瘤）的方法。 在一个优选的实施方案中，实施本发明以诱导现有癌症或肿瘤的消退和/或预防转移和/或防止转移性结节的生长。 在其他优选的实施方案中，本发明可用作预防，以通过针对高发病率癌症的特定肿瘤抗原的童年或成人接种计划来预防原发性癌症的发展。 在另一个优选的实施方案中，本发明提供了通过童年或成人疫苗程序建立针对通用人造肿瘤抗原的免疫应答的方法，从而提供了可在任何时间点用于治疗任何癌症的长期免疫应答， 后来在人生中发展。 本发明还提供了稳定表达人工抗原的癌症和肿瘤细胞，优选人造细胞表面抗原。
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公开(公告)号：EP1069908B1
公开(公告)日：2010-02-10
申请号：EP99919803.9
申请日：1999-04-08
CPC分类号： A61K39/0011 , A61K48/00 , A61K2039/5254 , A61K2039/5258
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公开(公告)号：EP1208217B1
公开(公告)日：2008-10-29
申请号：EP00963282.9
申请日：2000-08-30
CPC分类号： C12N15/87 , A61K48/00 , A61K2039/5256 , C12N15/86 , C12N2770/36143
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公开(公告)号：EP1012295B1
公开(公告)日：2004-10-06
申请号：EP96916547.1
申请日：1996-05-21
发明人： JOHNSTON, Robert, E. , DAVIS, Nancy, L. , SMITH, Jonathan, F. , PUSHKO, Peter , PARKER, Michael , LUDWIG, George
CPC分类号： C07K14/005 , A61K2039/5254 , C12N7/00 , C12N15/86 , C12N2770/36122 , C12N2770/36143 , C12N2770/36152 , C12N2770/36162 , C12N2840/20
摘要： The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least alphavirus one structural protein not encoded by the first helper RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell. Preferably, the helper cell also includes a replicon RNA encoding an alphavirus packaging sequence and an inserted heterogeneous RNA.
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公开(公告)号：EP1208217A1
公开(公告)日：2002-05-29
申请号：EP00963282.9
申请日：2000-08-30
CPC分类号： C12N15/87 , A61K48/00 , A61K2039/5256 , C12N15/86 , C12N2770/36143
摘要： The present invention provides compositions and methods for delivering a nucleotide sequence to a cell using an alphavirus vector that is complexed with an enhancing antibody that specifically binds to the alphavirus vector. Venezuelan Equine Encephalitis vectors are preferred. The cell may be a cell in vitro or in vivo. Alternatively, the cell may be removed from a subject, administered the alphavirus vector ex vivo and then administered to a subject. Antigen-presenting cells are preferred, with dendritic cells being more preferred. Also provided are methods of producing an immune response in a subject, e.g., for producing an immune response against an antigen associated with a pathogen or for immunotherapy of cancer of tumors.
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