公开(公告)号：EP0920510A1

公开(公告)日：1999-06-09

申请号：EP97935395.0

申请日：1997-08-08

申请人： The University of Saskatchewan

发明人： POTTER, Andrew, A. ,  MANNS, John, G.

IPC分类号： C12N15 ,  A61K39 ,  A61K47 ,  A61P15 ,  A61P35 ,  C07K5 ,  C07K7 ,  C07K14 ,  C07K16 ,  C07K19 ,  C12N1 ,  C12P21 ,  C12R1

CPC分类号： A61K39/0006 ,  A61K39/00 ,  A61K47/62 ,  A61K47/646 ,  A61K47/6829 ,  A61K47/6833 ,  A61K2039/6037 ,  C07K5/1008 ,  C07K5/1019 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/23 ,  C07K14/005 ,  C07K14/285 ,  C07K14/655 ,  C07K16/26 ,  C07K2319/00 ,  C12N2720/12322

摘要： New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.