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1.发明公开CYANOVIRIN CONJUGATES, MATRIX-ANCHORED CYANOVIRIN AND ANTI-CYANOVIRIN ANTIBODY, AND RELATED COMPOSITIONS AND METHODS OF USE 有权蓝藻抗病毒蛋白偶联物，MATRIX锚蓝藻抗病毒和抗蓝藻抗病毒抗体和相关组合物及其应用
公开(公告)号：EP1162992A2
公开(公告)日：2001-12-19
申请号：EP00913869.4
申请日：2000-03-10
发明人： BOYD, Michael, R.
CPC分类号： A61K38/164 , A61K47/6817 , A61K47/6833 , A61L2/0082 , A61L2/0088 , A61L2/18 , A61L2/186 , A61L2/23 , C07K14/195
摘要： The present invention provides, among other things, methods of removing virus from a sample, compositions treated in accordance with such methods, a composition comprising a naturally-occurring non- infectious HIV comprising gp120, a composition comprising a solid support matrix to which is attached a cyanovirin or a conjugate thereof, a conjugate comprising a cyanovirin coupled to an anti-cyanovirin antibody or at least one effector component, a composition comprising such a conjugate, methods of inhibiting prophylactically or therapeutically a viral infection of a host, methods of inducing an immune response to a virus in an animal, and a matrix-anchored anti-cyanovirin antibody.
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公开(公告)号：EP0920510A1
公开(公告)日：1999-06-09
申请号：EP97935395.0
申请日：1997-08-08
IPC分类号： C12N15 , A61K39 , A61K47 , A61P15 , A61P35 , C07K5 , C07K7 , C07K14 , C07K16 , C07K19 , C12N1 , C12P21 , C12R1
CPC分类号： A61K39/0006 , A61K39/00 , A61K47/62 , A61K47/646 , A61K47/6829 , A61K47/6833 , A61K2039/6037 , C07K5/1008 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K7/23 , C07K14/005 , C07K14/285 , C07K14/655 , C07K16/26 , C07K2319/00 , C12N2720/12322
摘要： New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.
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公开(公告)号：EP0920510B1
公开(公告)日：2005-07-27
申请号：EP97935395.0
申请日：1997-08-08
IPC分类号： C12N15/16 , C12N15/31 , C12N15/62 , C12N1/21 , C07K14/285 , C07K7/23 , A61K38/09 , A61K39/385
CPC分类号： A61K39/0006 , A61K39/00 , A61K47/62 , A61K47/646 , A61K47/6829 , A61K47/6833 , A61K2039/6037 , C07K5/1008 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K7/23 , C07K14/005 , C07K14/285 , C07K14/655 , C07K16/26 , C07K2319/00 , C12N2720/12322
摘要： New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.
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4.发明授权CYANOVIRIN CONJUGATES, MATRIX-ANCHORED CYANOVIRIN AND ANTI-CYANOVIRIN ANTIBODY, AND RELATED COMPOSITIONS AND METHODS OF USE 有权蓝藻抗病毒蛋白偶联物，MATRIX锚蓝藻抗病毒和抗蓝藻抗病毒抗体和相关组合物及其应用
公开(公告)号：EP1162992B1
公开(公告)日：2005-05-25
申请号：EP00913869.4
申请日：2000-03-10
发明人： BOYD, Michael, R.
CPC分类号： A61K38/164 , A61K47/6817 , A61K47/6833 , A61L2/0082 , A61L2/0088 , A61L2/18 , A61L2/186 , A61L2/23 , C07K14/195
摘要： The present invention provides, among other things, methods of removing virus from a sample, compositions treated in accordance with such methods, a composition comprising a naturally-occurring non- infectious HIV comprising gp120, a composition comprising a solid support matrix to which is attached a cyanovirin or a conjugate thereof, a conjugate comprising a cyanovirin coupled to an anti-cyanovirin antibody or at least one effector component, a composition comprising such a conjugate, methods of inhibiting prophylactically or therapeutically a viral infection of a host, methods of inducing an immune response to a virus in an animal, and a matrix-anchored anti-cyanovirin antibody.
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公开(公告)号：EP0808369A1
公开(公告)日：1997-11-26
申请号：EP96900796
申请日：1996-01-24
申请人： UNIV SASKATCHEWAN
发明人： POTTER ANDREW A , MANNS JOHN G
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K47/48 , A61P43/00 , C07K5/103 , C07K5/11 , C07K5/113 , C07K5/117 , C07K7/23 , C07K14/14 , C07K14/285 , C07K14/655 , C07K16/26 , C07K19/00 , C12N1/21 , C12N15/00 , C12N15/31 , C12P21/02 , C12R1/19 , C12R1/91 , C12N15/62 , A61K38/09 , A61K39/385
CPC分类号： C07K5/1024 , A61K39/00 , A61K39/0006 , A61K47/62 , A61K47/646 , A61K47/6829 , A61K47/6833 , A61K2039/6037 , C07K5/1008 , C07K5/1019 , C07K5/1021 , C07K7/23 , C07K14/005 , C07K14/285 , C07K14/655 , C07K16/26 , C07K2319/00 , C12N2720/12322
摘要： New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which comprise a leukotoxin polypeptide fused to a selected GnRH multimer which consists essentially of at least one repeating GnRH decapepetide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimer fused thereto.
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