公开(公告)号：EP4446346A1

公开(公告)日：2024-10-16

申请号：EP22904306.2

申请日：2022-12-08

申请人： The University of Tokyo ,  Asahi Kasei Kabushiki Kaisha

发明人： HARA, Yuichi ,  HARANO, Kodai ,  SANO, Ayae ,  ITO, Taichi ,  OKI, Yuichiro ,  INAGAKI, Natsuko

IPC分类号： C07K17/12 ,  C08J9/28 ,  C12N5/0789

摘要： Provided are: cellulose porous particles which have large surface areas on which cells can be attached, and on which cells can be adhered easily, and which rarely undergo the detachment of cells when the cells are cultured at a high density; and a microcarrier for culture use, which comprises the cellulose porous particles. The cellulose porous particles according to the present invention are composed of cellulose, in which the cellulose constituting the cellulose porous particles is modified by a cationic substituent and the cellulose constituting the cellulose porous particles has a polypeptide bound thereto.

公开(公告)号：EP4198060A1

公开(公告)日：2023-06-21

申请号：EP21855968.0

申请日：2021-08-10

申请人： The University of Tokyo ,  Mochida Pharmaceutical Co., Ltd.

发明人： ITO, Taichi ,  OHTA, Seiichi ,  QI, Pan ,  CHANDEL, Arvind Kumar Singh ,  ISAJI, Mitsuko

IPC分类号： C08B11/15 ,  A61K9/06 ,  A61K9/48 ,  A61K45/00 ,  A61K47/61 ,  C08B37/02 ,  C08B37/04 ,  C08B37/08

摘要： To provide a novel polysaccharide derivative which can be used to form a conjugate with a drug and can be used as a medical material, and a polysaccharide derivative-drug conjugate which uses the same. A polysaccharide derivative obtained by introducing a group represented by formula (A) to a polysaccharide which is acidic, basic or both, and a polysaccharide derivative-drug conjugate of said polysaccharide derivative and a drug.

公开(公告)号：EP3485921A1

公开(公告)日：2019-05-22

申请号：EP17827728.1

申请日：2017-07-13

申请人： Mochida Pharmaceutical Co., Ltd. ,  The University Of Tokyo

发明人： ITO, Taichi ,  OHTA, Seiichi ,  KOKUDO, Norihiro ,  ISAJI, Mitsuko ,  SHIMIZU, Satoshi

IPC分类号： A61L31/04 ,  A61L31/12 ,  A61L31/14

摘要： [Problem] An adhesion-preventing material having a high adhesion-preventing effect has been demanded.
[Solution] An adhesion-preventing material including a sterilized biocompatible sponge-like laminate, wherein the sponge-like laminate comprises a sponge-like first layer and a sponge-like second layer each of which is at least partially crosslinked with a curing agent and comprises a low-endotoxin alginic acid monovalent metal salt, the alginic acid monovalent metal salt in the first layer has a weight average molecular weight of 10,000 to 2,000,000, the alginic acid monovalent metal salt in the second layer has a weight average molecular weight of 1,000 to 1,000,000, the weight average molecular weights are measured by a GPC-MALS method after a decrosslinking treatment, and the weight average molecular weight of the alginic acid monovalent metal salt in the first layer is higher than that in the second layer.

公开(公告)号：EP4302753A1

公开(公告)日：2024-01-10

申请号：EP22763278.3

申请日：2022-03-01

申请人： The University of Tokyo ,  DAIKIN INDUSTRIES, LTD.

发明人： ITO, Taichi ,  CHANDEL, Arvind Kumar Singh ,  HAMADA, Tomohito ,  SAGISAKA, Shigehito ,  KISHIKAWA, Yosuke

IPC分类号： A61K9/10 ,  A61K47/32 ,  A61K47/34 ,  B01J13/12 ,  A61K35/14

摘要： An object of the present invention is to provide a novel microparticle. The present invention provides as a means for achieving the object, a core-shell microparticle comprising a shell comprising at least one polymer selected from the group consisting of fluorine-containing polymers, fluorine-free vinyl polymers, and silicone polymers, and a core comprising a fluorocarbon.

公开(公告)号：EP3741400A1

公开(公告)日：2020-11-25

申请号：EP18899891.8

申请日：2018-01-15

申请人： Mochida Pharmaceutical Co., Ltd. ,  The University of Tokyo

发明人： ITO, Taichi ,  OHTA, Seiichi ,  HASEGAWA, Kiyoshi ,  ISAJI, Mitsuko ,  SHIMIZU, Satoshi ,  TANAKA, Daichi

IPC分类号： A61L31/12 ,  A61L31/04 ,  B32B5/32 ,  B32B27/00 ,  B32B27/26

摘要： The purpose of the present invention is to provide an anti-adhesion material having a high anti-adhesion effect. The present invention pertains to an anti-adhesion material comprising a biocompatible sponge-like layered body having a sponge-like first layer and a sponge-like second layer both being at least partially crosslinked with a curing agent and comprising a low endotoxin monovalent metal salt of alginic acid. The monovalent metal salt of alginic acid in the first layer has a weight average molecular weight of 30000 to 300000. The monovalent metal salt of alginic acid in the second layer has a weight average molecular weight of 1000 to 200000. The weight average molecular weights are determined by GPC-MALS after a de-crosslinking treatment. The weight average molecular weight of the monovalent metal salt of alginic acid in the first layer is higher than the weight average molecular weight of the monovalent metal salt of alginic acid in the second layer.