公开(公告)号：EP4151278A1

公开(公告)日：2023-03-22

申请号：EP21788532.6

申请日：2021-04-13

申请人： The University of Tokyo ,  Savid Therapeutics Inc. ,  Fukushima Medical University

发明人： KANAI Motomu ,  YAMATSUGU Kenzo ,  TATSUMI Toshifumi ,  KODAMA Tatsuhiko ,  SUGIYAMA Akira ,  TSUKAGOSHI Masanobu ,  TODA Yuzo ,  WASHIYAMA Kohshin ,  TAKAHASHI Kazuhiro ,  ZHAO Songji ,  UKON Naoyuki ,  SUZUKI Miho

IPC分类号： A61P35/00 ,  C07D519/00 ,  A61K47/66 ,  A61K47/68 ,  A61K51/04 ,  A61K51/10 ,  G01N33/53

摘要： It is an object of the present invention to provide a novel halogenated biotin-modified dimer capable of performing imaging diagnosis or treatment. According to the present invention, a compound represented by the following formula (1) or a salt thereof is provided:

wherein L 1 represents a trivalent linking group, L 2 represents a divalent linking group, Hal represents a halogen, p represents an integer of 1 to 5, and q, r, s, and t each independently represent an integer of 1 to 8.

公开(公告)号：EP4101506A1

公开(公告)日：2022-12-14

申请号：EP21750642.7

申请日：2021-02-04

申请人： The University of Tokyo ,  Savid Therapeutics Inc.

发明人： KANAI Motomu ,  YAMATSUGU Kenzo ,  TATSUMI Toshifumi ,  TAKAHASHI Kazuki ,  KODAMA Tatsuhiko ,  SUGIYAMA Akira ,  TSUKAGOSHI Masanobu ,  TODA Yuzo

IPC分类号： A61P35/00 ,  C09B47/30 ,  C07K16/28 ,  C07F7/10 ,  C07D487/22 ,  A61K47/55 ,  A61K47/64 ,  A61K47/68 ,  A61K41/00 ,  A61K31/695

摘要： Objects of the present invention are to provide a novel phthalocyanine dye for use in photoimmunotherapy, and a method for producing the same, and to provide a conjugate of the above-described phthalocyanine dye and an antibody or a peptide. According to the present invention, a compound represented by the following formula (1) or a salt thereof is provided:

wherein X represents a substituent having a hydrophilic group at the terminus thereof; L 3 , L 4 , L 5 , and L 6 each independently represent a divalent linking group; Y represents a group capable of binding to an antibody or a peptide; R 3 represents a substituent, such as an alkyl group containing 1 to 6 carbon atoms, an alkoxy group containing 1 to 6 carbon atoms, a halogen atom, -SR 11 , -SOR 12 , an aryl group containing 6 to 10 carbon atoms, -N(R 13 )(R 14 ), or -NO 2 , wherein when a plurality of R 3 s are present, the plurality of R 3 s may be identical to or different from one another; and s represents an integer of 0 to 4.