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公开(公告)号：EP4002426A1
公开(公告)日：2022-05-25
申请号：EP21208073.3
申请日：2021-11-12
申请人： Thermo Finnigan LLC
发明人： SILVEIRA, Joshua A. , LINDSETH, Dale , SCHULTZ, Gary A. , POLTASH, Michael L. , ROBSON, Brandon Howard , WOUTERS, Eloy R.
摘要： Packed-tip electrospray ionization (ESI) emitters for mass spectrometry are described. In one aspect an ESI emitter stores a first type of particle. A liquid chromatography (LC) column is coupled with the emitter via a junction. The LC column stores a different type of particle than the ESI emitter to facilitate better chromatographic and ESI performance.
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公开(公告)号：EP4057321A2
公开(公告)日：2022-09-14
申请号：EP22161096.7
申请日：2022-03-09
申请人： Thermo Finnigan LLC
摘要： An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
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公开(公告)号：EP4411370A2
公开(公告)日：2024-08-07
申请号：EP24155453.4
申请日：2024-02-02
申请人： Thermo Finnigan LLC
CPC分类号： G01N30/88 , G01N30/7266 , G01N2030/880420130101 , G01N35/00584
摘要： Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a chromatography instrument support apparatus may include: first logic to receive, from an imaging device, image data regarding chromatography instrumentation; second logic to determine a state of the chromatography instrumentation by processing the imaging device through a machine-learning computational model; and third logic to display the state of the chromatography instrumentation.
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公开(公告)号：EP3826049A1
公开(公告)日：2021-05-26
申请号：EP20208712.8
申请日：2020-11-19
申请人： Thermo Finnigan LLC
摘要： A method for cleaning an electrospray emitter of a mass spectrometer, comprises: (a) changing a mode of operation of the electrospray emitter from a stable jet mode of operation to a dripping mode or a pulsating mode of operation by lowering a magnitude of a voltage applied between an counter electrode and the electrospray emitter; (b) causing a cleaning solvent to flow through the electrospray emitter at least until a droplet of the cleaning solvent forms on an exterior surface of the electrospray emitter while operating the electrospray emitter in the dripping mode of operation; and (c) causing the droplet to dislodge from the electrospray emitter exterior.
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公开(公告)号：EP4131334A1
公开(公告)日：2023-02-08
申请号：EP22188097.4
申请日：2022-08-01
申请人： Thermo Finnigan LLC
发明人： LINDSETH, Dale , SILVEIRA, Joshua A. , POLTASH, Michael L , WOUTERS, Eloy R. , MINKLER, David E.
摘要： An electrospray ionization system used in mass spectrometry provides for improved current measurement. The system includes a fluid union (224), a fluid column (208) coupled with a first port (238) of the fluid union, a power source (202, 504) coupled with the fluid union and configured to apply a voltage potential to the fluid union, and an electrospray emitter (232, 234, 506) coupled with a second port of the fluid union. The power source is coupled with the first port and configured to apply the voltage potential to the first port to restrict current leakage from the fluid union. The current sensing circuit (206, 500) is configured to determine an electrical current flow between the power source and the at least one of the fluid union and the first port.
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公开(公告)号：EP3879262A1
公开(公告)日：2021-09-15
申请号：EP21161725.3
申请日：2021-03-10
申请人： Thermo Finnigan LLC
IPC分类号： G01N27/622 , H01J49/00
摘要： An ion mobility separation apparatus comprises: a compartment having a gas therein; an electrode structure comprising a first plurality of electrodes within the compartment, the electrode structure defining a longitudinal axis; one or more power supplies electrically coupled to the electrodes, wherein the plurality of electrodes and the power supply are configured to maintain an electrical pseudopotential well encompassing and disposed parallel to the longitudinal axis and to maintain an electric field directed parallel to the longitudinal axis; an entrance ion gate disposed at a first end of the longitudinal axis; an exit ion gate disposed at a second end of the longitudinal axis; and at least one additional ion gate disposed between the entrance and exit ion gates.
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公开(公告)号：EP4102539A1
公开(公告)日：2022-12-14
申请号：EP22178092.7
申请日：2022-06-09
发明人： MAKAROV, Alexander A. , WOUTERS, Eloy R. , SILVEIRA, Joshua A. , SKOBLIN, Mikhail G. , KOZLOVSKIY, Viacheslav I.
摘要： A mass spectrometry method comprises: (1) introducing ions and gas into an first electrode section of an ion transport apparatus through a slot of an ion transfer tube, the ion tunnel section comprising a first longitudinal axis that is contained within a slot plane of the ion transfer tube, the first longitudinal axis not intersecting an outlet of the ion transfer tube, wherein the apparatus further comprises: (a) a second electrode section configured to receive the ions from the first electrode section and comprising a second longitudinal axis that is not coincident with the first longitudinal axis; and (b) an ion outlet aperture ;(2) providing voltages to electrodes of the ion transport apparatus that urge the ions to migrate towards the first longitudinal axis within the first electrode section; and (3) exhausting gas through a port that is offset from the ion outlet aperture.
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公开(公告)号：EP4057321A3
公开(公告)日：2022-11-16
申请号：EP22161096.7
申请日：2022-03-09
申请人： Thermo Finnigan LLC
摘要： An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.
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公开(公告)号：EP3671810A1
公开(公告)日：2020-06-24
申请号：EP19219040.3
申请日：2019-12-20
申请人： Thermo Finnigan LLC
摘要： An ion separation device comprising a plurality of electrodes arranged in a two-dimensional grid, a gas supply configured to provide a gas flow along the first direction, and an ion inlet arranged to receive ions. The plurality of electrodes is configured to create one or more pseudopotential barriers of increasing magnitude along a first direction. A drag force is applied to the ions by the gas flow is opposed by a pseudopotential gradient of the plurality of electrodes.
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